Follow
International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2019) [Effective from January 1, 2019]For more details click here

Login as a Reviewer

Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

See Guidelines to Authors
Current Issues

Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(12): 2655-2668
DOI: https://doi.org/10.20546/ijcmas.2017.612.307


Immune Response Study to Live Infectious Bursal Disease Vaccines in Broiler Chickens
Pooja Kundu1*, G. Narang2, Rajesh Chhabra3, Sushma Kajal2, N.K. Mahajan1 and Naresh Kakkar4
1Department of Veterinary Public Health and Epidemiology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar- 125004, Haryana, India
2Department of Veterinary Pathology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar- 125004, Haryana, India
3College Central Lab, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar- 125004, Haryana, India
4Department of Veterinary Microbiology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar- 125004, Haryana, India
*Corresponding author
Abstract:

Vaccination plays an important role in the successful control of infectious bursal disease (IBD). Despite the regular use of IBD vaccines, the disease prevails in Haryana state and affects the flocks of different age groups. Control of IBD poses one of the most challenging tasks in the poultry health management. To evaluate the vaccine immune response of IBD vaccines, an experimental study was conducted using two commercial intermediate plus vaccines P and Q. The level of maternal antibodies (MAbs) ranged from 6834.6 to 9925.60 in day old chicks. In experimental birds the age of vaccination was calculated on the basis of MAb titres and it came to be 17 days of age. The mean maternal antibody titre of chicks at 1, 7 and 14 day age was 7874.21, 2449.4 and 1089.9. The mean MAb titre showed a steady decline in the titre from day old age to 14th day of age. Vaccine P showed static increase in ELISA antibody titres from 7 DPV however vaccine Q showed quite higher level of antibody titres on 7 DPV itself which remain protective till the end of experiment in both. CD4+ cells increased at 7 DPV, decreased at 14 and 21 DPV, again increased at 28 DPV. CD8+ cells increased at 7 DPV, decreased at 14 DPV, again increased at 21 and 28 DPV. This decrease in CD4+ and CD8+ cells at 14 and 21 DPV is probably due immunosuppressive effect of IBD vaccines. Both vaccines P and Q provided protective immunity from 7 DPV till the end of experiment but with immunosuppressive effect of IBD vaccines. Further studies are required to see the variation in protection and to monitor immunosuppression induced by different vaccine strain available in our area.


Keywords: Immune response, Vaccination, Antibodies.
Download this article as Download

How to cite this article:

Pooja Kundu, G. Narang, Rajesh Chhabra, Sushma Kajal, N.K. Mahajan and Naresh Kakkar. 2017. Immune Response Study to Live Infectious Bursal Disease Vaccines in Broiler Chickens.Int.J.Curr.Microbiol.App.Sci. 6(12): 2655-2668. doi: https://doi.org/10.20546/ijcmas.2017.612.307