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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(12): 1180-1188
DOI: https://doi.org/10.20546/ijcmas.2017.612.133


Pathomorphological Alterations in Various Organs of Experimentally Induced Listeriosis in Mice
M.A. Malik1, J.K. Sharma2, Moien Javaid1*, Maninder Singh1 and Raghubir Singh1
1Division of Veterinary Public Health and Epidemiology, F.V.Sc & A.H., R.S.Pura,
Jammu, SKUAST-J, India
2Department of Veterinary Public Health and Epidemiology, GADVASU,Ludhiana, Punjab, India
*Corresponding author
Abstract:

Listeria monocytogenes isolates were intraperitoneally administered into the mice to evaluate the histopathological changes in various organs of the infected mice. The study consisted of nine groups of mice each group comprising of three mice. Inocula prepared from seven different isolates of Listeria monocytogenes were administered into seven different groups. The study also included one positive control (inoculated with reference strain) and one negative control (inoculated with normal saline) groups. The total period of study was 10 days. The pathogenicity of isolates and the reference strain was studied by injecting a fixed dose of organisms intraperitoneally into mice. The death of mice occurred between 2nd to 6th post exposure day. Four isolates killed more than 50% of mice, two isolates killed more than 30% of mice where as one isolate caused no death. The histopathological examination revealed more severe changes in liver and included microabscesses. The section of kidneys of infected mice revealed mild focal vacuolar degeneration in cortical epithelial cells. The sections of spleen, myocardium and brain also revealed altered histopathogical changes.


Keywords: Listeria monocytogenes, Inocula, Microabscesses, Vacuolar degeneration, Pathogenicity, Intraperitoneally
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How to cite this article:

Malik, M.A., J.K. Sharma, Moien Javaid, Maninder Singh and Raghubir Singh. 2017. Pathomorphological Alterations in Various Organs of Experimentally Induced Listeriosis in Mice.Int.J.Curr.Microbiol.App.Sci. 6(12): 1180-1188. doi: https://doi.org/10.20546/ijcmas.2017.612.133