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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(12): 729-736
DOI: https://doi.org/10.20546/ijcmas.2017.612.076


High-Level Resistance to Ciprofloxacin and Rising MIC to Ceftriaxone and Azithromycin among Enteric Fever Isolates from a Tertiary Care Center, Puducherry, India
K. Sandhya Bhat, S. Anandhalakshmi*, Desdemona Rasitha, Shreyas Venkataraman and Reba Kanungo
Department of Microbiology, Pondicherry Institute of Medical Sciences, Puducherry, India
*Corresponding author
Abstract:

Enteric fever is an important public health problem in India and accounts for high morbidity and mortality. Specific antibiotic therapy is the mainstay of management of enteric fever. Emergence of multi drug resistant Salmonella isolates has led to the need of continuous monitoring of susceptibility pattern to these agents. Hence this study was conducted to detect minimum inhibitory concentrations of ciprofloxacin, ceftriaxone and azithromycin among enteric fever isolates and to formulate an antibiotic policy. A prospective study was conducted for three years duration among enteric fever isolates. Susceptibility was determined phenotypically by disk diffusion testing and MIC by E-strip testing. Total of 62 Salmonella isolates from blood samples of enteric fever patients were studied. Salmonella paratyphi A isolates outnumbered Salmonella typhi isolates. Ciprofloxacin resistance was observed among 16 (25.8%) isolates with MIC of ≥1 μg/mL. MIC estimation was better predictor of resistance in vivo as compared to disk diffusion testing. We observed rising MIC to ceftriaxone and azithromycin. As MIC is superior to disk diffusion testing in predicting the clinical outcome, susceptibility reporting should depend on MIC results, if facilities are available to prevent treatment failures.


Keywords: Enteric fever, Salmonella typhi, Salmonella parattyphi A, Multi drug resistant, Rising MIC, Antimicrobial susceptibility testing, Ciprofloxacin resistance.
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How to cite this article:

Sandhya Bhat, K., S. Anandhalakshmi, Desdemona Rasitha, Shreyas Venkataraman and Reba Kanungo. 2017. High-Level Resistance to Ciprofloxacin and Rising MIC to Ceftriaxone and Azithromycin among Enteric Fever Isolates from a Tertiary Care Center, Puducherry, India.Int.J.Curr.Microbiol.App.Sci. 6(12): 729-736. doi: https://doi.org/10.20546/ijcmas.2017.612.076