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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(11): 5419-5424
DOI: https://doi.org/10.20546/ijcmas.2017.611.518


MicroRNAs as Early Detection Biomarker in Cancer
Omer Khalil Baba1, Aarif Ali1, Majid Shafi2, Ishraq Hussain1, S. Mudasir Rashid1, Rahil Razak Bhat1, Bilal Ahmad Mir1, Sheikh Bilal Ahmad1, Showkeen Muzamil1 and Manzoor ur Rahman Mir1*
1Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e Kashmir University of Agricultural Science and Technology-Kashmir (SKUAST-K), Srinagar, J&K-190006, India
2Division of Veterinary Pathology, Faculty of Veterinary Sciences and Animal Husbandry,Sher-eKashmir University of Agricultural Science and Technology-Kashmir (SKUAST-K), Srinagar, J&K-190006, India
*Corresponding author
Abstract:

MicroRNAs are 20–24-nucleotide-long noncoding RNAs that bind to the target mRNAs at the 3′ UTR (untranslated region) and regulate the expression of various oncogenes or tumor suppressor genes. Under various physiological conditions the ability of miRNAs to control gene expression has widely focused and gained their attention. It has also been reported that there is a link between deregulated expression of miRNAs to different disease states. In the last few years there has a great trend to know the biological role of mircoRNA (miRNA) in normal cellular as well as in disease processes. The expression profiling of miRNAs has clearly assessed their role as diagnostic and prognostic biomarkers which will help clinicians to assess tumor initiation, progression and response to treatment in cancer patients. In the development of various stages of cancer, the role and involvement of miRNAs has been revealed. This review focuses on the association of miRNAs with that of cancer and highlights the role of miRNAs in clinical practice, such as diagnosis, prognosis and detection.


Keywords: miRNAs, Biogenesis, Dysregulation, Biomarkers.
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How to cite this article:

Omer Khalil Baba, Aarif Ali, Showkeen Muzamil, Majid Shafi, Shahzada Mudasir, Rahil Razak Bhat, Bilal Ahmad Mir and Manzoor ur Rahman Mir. 2017. MicroRNAs as Early Detection Biomarker in Cancer.Int.J.Curr.Microbiol.App.Sci. 6(11): 5419-5424. doi: https://doi.org/10.20546/ijcmas.2017.611.518