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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(11): 2655-2663
DOI: https://doi.org/10.20546/ijcmas.2017.611.312


In vitro Susceptibility of Multidrug-Resistant Klebsiella pneumoniae Isolates from an Egyptian Tertiary Care Hospital to Tigecycline and Colistin
Rania Abd El-Hamid El-Kady* and Nawal Salama Gouda
Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
*Corresponding author
Abstract:

The evolution of multidrug-resistant (MDR) Klebsiella pneumoniae constitutes a foremost public health issue, owing to the relatively limited antibiotic arsenal. Thereby, this research was undertaken to explore the in vitro susceptibility of MDR K. pneumoniae isolates from Mansoura University Hospital (MUH), Egypt to tigecycline and colistin. Over a 12-month study period, a total of 120 K. pneumoniae isolates were recovered. The MDR K. pneumoniae isolates accounted for 49.2% (59 out of 120). Amongst these isolates, 91.5% (54/59) were susceptible to tigecycline by Etest (MICs range; 0.25-1 μg/ml, MIC50; 0.5 μg/ml, and MIC90; 1 μg/ml), whereas 89.8% (53/59) were colistin-susceptible (MICs range; 0.5-2 μg/ml, MIC50; 1 μg/ml, and MIC90; 2 μg/ml). Extended-spectrum β-lactamase (ESBL) production was verified in 71.2% of the MDR strains, of which 95.2% and 92.9% were susceptible to tigecycline and colistin, respectively. In addition, 87.5% and 81.25% of the carbapenemase-positive-MDR K. pneumoniae strains displayed sensitivity to tigecycline and colistin, respectively. In conclusion, tigecycline and colistin exhibited striking in vitro activity against MDR K. pneumoniae isolates, including ESBL- and carbapenemase-producers. However, judicious use of these antibiotics is mandatory to avert the forthcoming threat of resistance to promising antibiotic classes.


Keywords: Klebsiella pneumoniae, Multidrug-resistant (MDR), Tigecycline, colistin, Minimum inhibitory concentrations (MICs), Etest.
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How to cite this article:

Rania Abd El-Hamid El-Kady and Nawal Salama Gouda. 2017. In vitro Susceptibility of Multidrug-Resistant Klebsiella pneumoniae Isolates from an Egyptian Tertiary Care Hospital to Tigecycline and Colistin.Int.J.Curr.Microbiol.App.Sci. 6(11): 2655-2663. doi: https://doi.org/10.20546/ijcmas.2017.611.312