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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Online ISSN : 2319-7706
Issues : 12 per year
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Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(5): 910-913
DOI: http://dx.doi.org/10.20546/ijcmas.2016.505.094


Determination of LD50 Value of Zinc Chloride on Swiss Albino Mice
Satish Kumar Yadav and A.V. Trivedi*
Department of Chemistry, Carrier Point University, National Highway -12, Alaniya,Kota 325003, Rajasthan, India
*Corresponding author
Abstract:

Toxicity of zinc chloride on Swiss albino mice of either sex was determined. Graphical method as described by Miller and Tainter was used for the determination of accurate value of LD50. Five groups of mice of either sex containing ten animals in each group were selected for the experiment. Five doses of zinc chloride which were near to the approximate LD50 viz., 1000, 1100, 1200, 1300 and 1400 mg/kg b. wt. were chosen and given orally. The animals were observed for 2 hour and then at 4, 6, 24, 72, and 96 hour for any toxic signs and symptoms. After 96 hour the number of deceased mice in each group was counted and % mortality were calculated. LD50 of zinc chloride was found to be 1230 mg/kg b.wt. The Standard error (SE) of the LD50 was calculated using the formula: Approx. SE of LD50 = (Log LD84 - Log LD16) / 2N, and found to be 129.69. Thus LD50 of zinc chloride (ZnCl2) by oral route in Swiss albino mice was found

to be 1230 ± 129.69 with 95% confidence level.


Keywords: Toxicity,Swiss albino mice, Standard error, LD50 of zinc chloride,
percentage mortality.
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How to cite this article:

Satish Kumar Yadav and A.V. Trivedi. 2016. Determination of LD50 Value of Zinc Chloride on Swiss Albino Mice.Int.J.Curr.Microbiol.App.Sci. 5(5): 910-913. doi: http://dx.doi.org/10.20546/ijcmas.2016.505.094