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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(5): 419-429
DOI: http://dx.doi.org/10.20546/ijcmas.2016.505.044


Clinical, Laboratory, and Virological Profiles of Patients with Hepatitis C and B Co-infection in Upper Egypt
Khairy H. Morsy1* and Mohamed A.A. Ghaliony2
1Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Sohag University, Egypt
2Tropical Medicine and Gastroenterology Department, Faculty of Medicine,Assiut University, Egypt
*Corresponding author
Abstract:

HCV/HBV co-infection most frequently occurs in specific high-risk populations.
The present study was aimed to determine the Clinical, laboratory and virological characteristics of patients with hepatitis C and B co-infection. This study included 72 patients with positive both hepatitis B surface antigen (HBs Ag) and HCV Abs. Clinical data, laboratory and imaging data were collected. Quantitative HBV-DNA polymerase chain reaction (HBV-DNA-PCR) and HCV-RNA-PCR assays results were studied. For comparative purposes, two matched groups of mono-infection were included as control groups.  Liver cirrhosis was found in 30.6% of patients with chronic hepatitis C and B virus co-infection, but only in 3.7% of patients with chronic hepatitis C virus infection and 5% of patients with chronic hepatitis B virus infection. Hepatocellular carcinoma was found in 13.9% of patients with chronic hepatitis C and B virus co-infection, and only in 2.5% of patients with chronic hepatitis B virus infection.HCV PCR was positive in 75% of patients with chronic hepatitis C and B virus co-infection and in 93.7% of patients with chronic hepatitis C alone, while HBV PCR was positive in only 4.2% of patients with chronic hepatitis C and B virus co-infection and in 73.7% of patients with chronic hepatitis B alone.


Keywords: HCV,HBV,Co-infection, Egypt,Liver cirrhosis,HCC.
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How to cite this article:

Khairy H. Morsy and Mohamed A.A. Ghaliony. 2016. Clinical, Laboratory, and Virological Profiles of Patients with Hepatitis C and B Co-infection in Upper Egypt.Int.J.Curr.Microbiol.App.Sci. 5(5): 419-429. doi: http://dx.doi.org/10.20546/ijcmas.2016.505.044