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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(9): 3562-3566
DOI: https://doi.org/10.20546/ijcmas.2017.609.438


Gene Polymorphism of Solute Carrier 30 A8 (SLC30A8) in Type 2 Diabetes Mellitus
Fasil Ali1, Aarif Ali1*, Showkeen Muzamil2, Omer Khalil Baba2, Aadil Ayaz3 and Mashooq Ahmad Dar1
1Department of Clinical Biochemistry University of Kashmir, Srinagar-190006, J&K, India
2Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, Sheri Kashmir University of Agricultural Science & Technology-Kashmir (SKUAST-K), Srinagar, J&K, India 190006.
3Department of Zoology and Biotechnology, HNBG University, Srinagar, Uttarakhand, India
*Corresponding author
Abstract:

Diabetes mellitus is a common metabolic disorder of carbohydrate, fat, and protein metabolism. It is characterized by increased glucose levels (hyperglycemia). Diabetes mellitus arises due to defects in insulin secretion or action, or both. Solute carrier family 30 (Zinc transporter) member 8 also known as SLC30A8 is a human gene that codes for a Zinc transporter which in turn is associated to insulin secretion in humans. In pancreatic islets, the production of insulin is linked with the transport of Zinc. This transport is assisted by zinc transporter ZnT- 8 which is a product of the SLC30A8 gene. The function of zinc transporter-8 (ZnT8) is to deliver zinc ion from the cytoplasm into insulin granules. As the insulin granules contain high amounts of zinc, the physiological role of secreted zinc remains elusive. Hence any alteration in the activity of ZnT-8 is expected to be associated with impaired glucose induced insulin response and promote progression from glucose intolerance to diabetes. Recent reports do emerge and confirm a role of SLC30A8 in diabetes. Here we possibly find an emerging role of ZnT-8 in the development of diabetes and discuss potential mechanisms of its involvement in the etiology of both forms of diabetes.


Keywords: Diabetes, Zinc-transporter-8, SLC30A8, Susceptibility, Resistance and Insulin secretion.
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How to cite this article:

Fasil Ali, Aarif Ali, Showkeen Muzamil, Omer Khalil Baba, Aadil Ayaz and Mashooq Ahmad Dar. 2017. Gene Polymorphism of Solute Carrier 30 A8 (SLC30A8) in Type 2 Diabetes Mellitus.Int.J.Curr.Microbiol.App.Sci. 6(9): 3562-3566. doi: https://doi.org/10.20546/ijcmas.2017.609.438