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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(9): 3367-3375
DOI: https://doi.org/10.20546/ijcmas.2017.609.415


Cholesterol-Lowering and Hepatoprotective Effect of Fruit Juice Extract of Azadirachta indica on Plasmodium berghei Infected Mice
I.O. Igwenyi1*, A.C. Eze2, P.M. Aja1, S.O. Elom3, A.J. Uraku1, J.N. Awoke1 and N.A. Obasi3
1Department of Biochemistry, Ebonyi University, Abakaliki, Ebonyi State, Nigeria
2Department of Biochemistry, Federal University, Oye-Ekiti, Ekiti State, Nigeria
3Department of Medical Biochemistry, Federal University, Ndufu-Alike Ikwo, Ebonyi State, Nigeria
*Corresponding author
Abstract:

The effect of fresh juice extract of Azadirachta indica on lipid profile and hepatic function of Plasmodium berghei infected albino mice were investigated. Thirty adult male mice were placed in five groups of six mice each, acclimatized for 7 days and used for the study. Group A was normal control and had free access to feed and water while groups B to E were infected with Plasmodium berghei, and confirmed of parasitamia on the third day. Groups C, D and E were further given standard anti malaria drug (5 mg/kg body weight of Artesunate), 4.3ml/kg and 8.6 ml/kg of fruit juice extract respectively for fourteen days and sacrificed. It was observed that parasitemia caused a marked increase in the activities of liver enzymes and in the levels of total protein, LDL-C and total cholesterol The result revealed that treatment with a standard drug and fruit juice extract significantly reduced (P<0.05) the activities of AST, ALT and ALP. Parasitemia increased the level of total bilirubin significantly (P<0.05) but treatment with standard drug and fruit juice extract lowered the level of the total bilirubin significantly (p˂0.05). Investigation of the effect on lipid profile revealed that the fruit juice extract has cholesterol lowering effect with a significant increase (p˂0.05) in the level of HDL-cholesterol and a significant decrease (p˂0.05) in the level of total cholesterol. However, there was no significant effect (p˃0.05) on the level of triacylglycerol upon treatment with the juice extract. The result has shown that fruit juice extract of Azadirachta indica has hepatoprotective property and lipid lowering (hypolipidemic) effect and may find useful application in the management of hepatic damage, oxidative stress and cardiovascular diseases.


Keywords: Fruit juice extract, Azadirachta indica, Liver enzymes, Plasmodium berghei, Cholesterol, Lipid profile.
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How to cite this article:

Igwenyi, I.O., A.C. Eze, P.M. Aja, S.O. Elom, A.J. Uraku, J.N. Awoke and Obasi, N.A. 2017. Cholesterol-Lowering and Hepatoprotective Effect of Fruit Juice Extract of Azadirachta indica on Plasmodium berghei Infected MiceInt.J.Curr.Microbiol.App.Sci. 6(9): 3367-3375. doi: https://doi.org/10.20546/ijcmas.2017.609.415