Follow
International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2019) [Effective from January 1, 2019]For more details click here

Login as a Reviewer

Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

See Guidelines to Authors
Current Issues

Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(5): 75-83
DOI: http://dx.doi.org/10.20546/ijcmas.2016.505.008


Synthesis of Some Sulfa Drug Derivatives as Antibacterial Agents
Salman A. Ali1, Anmar H. Jabbir1* and Rana A. Mohsie2
1Department of Chemistry, Faculty of Science, Al-Nahrain University, Baghdad, Iraq
2College of Applied Biotechnology, Al-Nahrain University, Baghdad, Iraq
*Corresponding author
Abstract:

Sulfa drugs are an important class of synthetic bacteriostatic antibiotics still used today for the treatment of bacterial infections and those caused by other microorganisms, sulfa drugs achieve this bacteriostatic action by inhibiting the synthesis of folic acid in bacteria. The current study has the aim of Synthesis of some of sulfa drug compounds and Study the biological activity of the synthesized compounds against two types of bacteria: Staphylococcus aureus (Gram positive) and Pseudomonas aeruginosa (Gram negative).These compounds were formed successfully by chlorosulfonation of acetanilide and the product was treated with different amines and finally amide hydrolysis was necessary to get agents that were analyzed for IR, UV and melting points. At last, we studied their antibacterial activity on certain types of bacteria. We carried out an antibacterial evaluation in vitro of a series of five synthetic sulfa drugs (IIIa, IIIb, IIIc, IIId and IIIe) and from the results, antibacterial activity studies indicate that halo substituted sulfonamide (compound IIIc) was more active than the other members.


Keywords: Sulfa drugs, Staphylococcus aureus, Pseudomonas aeruginosa, chlorosulfonation, IR, UV.
Download this article as Download

How to cite this article:

Salman A. Ali, Anmar H. Jabbir and Rana A. Mohsie. 2016. Synthesis of Some Sulfa Drug Derivatives as Antibacterial AgentsInt.J.Curr.Microbiol.App.Sci. 5(5): 75-83. doi: http://dx.doi.org/10.20546/ijcmas.2016.505.008