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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(9): 2097-2106
DOI: https://doi.org/10.20546/ijcmas.2017.609.258


Inhibition of Helicobacter pylori and Its Associated Urease by Two Regional Plants of San Luis Argentina
A.G. Salinas Ibáñez1, A.C. Arismendi Sosa1, F.F. Ferramola1, J. Paredes2, G. Wendel2, A.O. Maria2 and A.E. Vega1*
1Área Microbiología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis. Ejercito de los Andes 950 Bloque I, Primer piso. CP5700, San Luis, Argentina
2Área de Farmacología y Toxicología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis. Chacabuco y Pedernera. CP5700, San Luis, Argentina
*Corresponding author
Abstract:

The search of alternative anti-Helicobacter pylori agents obtained mainly of medicinal plants is a scientific area of great interest. The antimicrobial effects of Litrahea molleoides and Aristolochia argentina extracts against sensible and resistant H. pylori strains, were evaluated in vitro. Also, the urease inhibition activity and the effect on the ureA gene expression mRNA was evaluated. The L. molleoides and A. argentinae extracts showed antimicrobial activity against all strains assayed. Regardless of the extract assayed a decrease of viable count of approximately 2 log units on planktonic cell or established biofilms in H. pylori strains respect to the control was observed (p<0.05). Also, both extracts demonstrated strong urease inhibition activity on sensible H. pylori (p<0.05). In all strains, the ureA gene expression was down regulation independently of extracts used. The promising results of this work suggest that both L. molleoides and A. argentina, two traditional medicinal plant of Cuyo region, could be used as H. pylori alternative treatment that could attenuate virulence of bacterium and enable the host immune system to combat infection.


Keywords: Helicobacter pylori, Inhibition urease, Plants.
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How to cite this article:

Salinas Ibáñez, A.G., A.C. Arismendi Sosa, F.F. Ferramola, J. Paredes, G. Wendel, A.O. Maria and Vega, A.E. 2017. Inhibition of Helicobacter pylori and Its Associated Urease by Two Regional Plants of San Luis Argentina.Int.J.Curr.Microbiol.App.Sci. 6(9): 2097-2106. doi: https://doi.org/10.20546/ijcmas.2017.609.258