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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(1): 411-423
DOI: http://dx.doi.org/10.20546/ijcmas.2016.501.041


Beneficial Effects of Diet Supplementation with Nigella sativa (Black Seed) and Sesame Seeds in Alloxan-Diabetic Rats
Thanaa A.A. Ibrahiem
Family and Child Sciences Department Nutrition and Food Science, Faculty of Arts and Sciences, Qassim University, Onaizh Soudia, Saudi Arabia
*Corresponding author
Abstract:

This study was performed to assess the effect of diet supplementation with Nigella sativa (NS) and Sesame seeds (SS) on body weight, immune status, blood glucose (BG), insulin, total cholesterol (TC), triglycerides (TG) and kidney function parameters as well as on activities of renal tissue antioxidant enzymes in diabetic rats. Forty nine mature Sprague Dawley male rats were randomized into 7 groups (n= 7). Group (1) was used as a negative control and fed on basal diet, while the remaining 6 groups were rendered diabetic by intraperitoneal injection of alloxan (120 mg/kg). After induction of diabetes, group (2) was kept positive control, while groups (3), (4), (5), (6) and (7) were fed on diet supplemented with 5 % NS; 10% NS; 5% SS; 10% SS and 5% NS+ 5% SS, respectively for 6 weeks. The initial and final body weights of rats were recorded. Blood samples were collected for estimation of tumor necrosis factor alpha (TNF- ), inflammatory cytokines IL-4 and IL-8, fasting BG, insulin, TC and TG levels, blood urea nitrogen (BUN), uric acid and creatinine (Cr) serum levels. Differential leucocytic count and activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) in kidney tissues were also determined. The results showed that diet supplementation with NS and SS significantly increased body weight and improved feed efficiency ratio of diabetic rats. Diet supplementation with NS and SS decreased the number of lymphocytes, decreased production of TNF- and cytokines IL4 and IL8; normalized BG, insulin, TC and TG and BUN and Cr levels. There were enhanced the activity of SOD, GPx and CAT enzymes in renal tissues of diabetic rats. In conclusion, diet supplementation with NS and SS has immunostimulant, antidiabetic, hypolipidemic, nephroprotective and antioxidant activities in diabetic rats. Therefore, intake of baked foods and sweets supplemented with NS and SS may be beneficial for patients who suffer from diabetes mellitus.


Keywords: Nigella sativa; Sesame seeds; Immunostimulant, Antidiabetic, Antioxidant
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How to cite this article:

Int.J.Curr.Microbiol.App.Sci. 5(1): 411-423. doi: http://dx.doi.org/10.20546/ijcmas.2016.501.041