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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(9): 1458-1463
DOI: https://doi.org/10.20546/ijcmas.2017.609.177


Pharmacokinetics and Anti-Inflammatory Activity of Andrographolide in Rats
L. Gondaliya Vaishali1, J.H. Patel1*, R.D. Varia1, S.K. Bhavsar1, Priti D. Vihol2 and Falguni D. Modi1
1Department of Pharmacology and Toxicology, Veterinary College, Navsari Agricultural University, Navsari, Gujarat, India
2Department of Veterinary Pathology, Veterinary College, Navsari Agricultural University, Navsari, Gujarat, India
*Corresponding author
Abstract:

The pharmacokinetics and anti-inflammatory activity of andrographolide (50 mg/kg) were studied following intramuscular administration in rats. Drug concentration in plasma was determined using High Performance Liquid Chromatography (HPLC). The mean peak plasma drug concentration of 3.17 ± 0.06 µg/mL was achieved at 4 h. The pharmacokinetic parameters like mean absorption half-life (t½α) (0.61 ± 0.07 h), elimination half-life (t½β) (1.3 ± 0.10 h), apparent volume of distribution (Vdarea) (6.9 ± 0.38 L/kg), area under plasma drug concentration-time curve (AUC0-∞) (13.7 ± 0.47 µg.h/mL), area under first moment curve (AUMC) (61.8 ± 3.44 µg.h2/mL), total body clearance (ClB) (3.6 ± 0.12 L/h/kg) and mean residence time (MRT) (4.6 ± 0.09 h) were observed. Following intramuscular administration of andrographolide, no anti-inflammatory effect was found in rats.


Keywords: Pharmacokinetic, Anti-inflammatory, Andrographolide, Rat.
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How to cite this article:

Gondaliya Vaishali, L., J.H. Patel, R.D. Varia, S.K. Bhavsar, Priti D. Vihol and Falguni D. Modi. 2017. Pharmacokinetics and Anti-Inflammatory Activity of Andrographolide in Rats.Int.J.Curr.Microbiol.App.Sci. 6(9): 1458-1463. doi: https://doi.org/10.20546/ijcmas.2017.609.177