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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(8): 2362-2368
DOI: https://doi.org/10.20546/ijcmas.2017.608.279


Promising Epigenetic Approaches Targeting TH17 in Autoimmune Diabetes among Chronic Hepatitis C Infection
Helal F. Hetta1* and Azza ElKady2
1Department of Medical Microbiology and Immunology, Faculty of Medicine,
Assiut University, Assiut, Egypt
2Sohag general hospital, Sohag University, Sohag, Egypt
*Corresponding author
Abstract:

The revolution of Epigenetics mechanisms including mi-RNA, DNA methylation and histone modification has drawn our attention to target Th17 cell regulatory cytokines and transcription factors which in turn will inhibit the production of interleukin 17 (IL17)- as it’s the key pro-inflammatory cytokine secreted by TH17 cells. The importance of targeting TH17 pathways in autoimmune diabetes come with the deeply ingrained idea of the great role of TH17 in immune pathogenesis of autoimmune diseases. Hepatitis C virus is one of the most common environmental factors which could trigger autoimmune diabetes by inducing local inflammation with cytokine and chemokine secretion (also called “bystander mechanism”.


Keywords: HCV, TH17, IL17, IL23, T1D, LADA, mi-RNA, Epigenetics.
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How to cite this article:

Helal F. Hetta and Azza ElKady. 2017. Promising Epigenetic Approaches Targeting TH17 in Autoimmune Diabetes among Chronic Hepatitis C Infection.Int.J.Curr.Microbiol.App.Sci. 6(8): 2362-2368. doi: https://doi.org/10.20546/ijcmas.2017.608.279