Follow
International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

Login as a Reviewer

Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

See Guidelines to Authors
Current Issues

Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(8): 3271-3279
DOI: https://doi.org/10.20546/ijcmas.2017.608.390


Evaluation of Hepatoprotective Property of Alternanthera sessilis in CCl4 Induced Hepatotoxicity in Rats
Anurag Borthakur1*, Pritam Mohan1, L.C. Lahon1, D.J. Kalita2, T. Rahman3 and Arup Sarmah4
1Department of Veterinary Pharmacology and Toxicology,
2Department of Veterinary Biochemistry,
3Department of Veterinary Pathology,
4Department of Statistics, College of Veterinary science, Ghy-22, Assam, India
*Corresponding author
Abstract:

A study was carried out to evaluate the hepatoprotective property of Alternanthera sessilis in CCl4 induced hepatotoxicity in rats. A total of 36 Wister rats were selected for the purpose of study, segregated into six different groups having six numbers of animals in each. Group T1 was kept as negative control and fed standard basal diet for a period of four weeks. Group T2 was kept as positive control and subjected to CCl4 plus liquid paraffin (50% v/v) treatment at the rate of 2ml/kg body weight twice a week for three weeks. Group T3 was treated with Silymarin at 100 mg/kg body weight concurrently with CCl4 toxicity for four weeks. Group T4, T5 and T6 were treated with aqueous extract of Alternanthera sessilis at 100 mg/kg body weight, 300 mg/kg body weight and 900 mg/kg body weight respectively and concomitantly with CCl4 toxicity. Results revealed that there was significant decrease in the various hepatic biomarkers viz. ALT, ALP, AST in the aqueous extract of Alternanthera sessilis treated groups T4, T5 and T6 as compared to positive control group T2. Histopathological examination also revealed that the hepatic damage wrought by CCl4 toxicity was significantly thwarted in the aqueous extract of Alternanthera sessilis treated groups. Thus it can be inferred that aqueous extract of Alternanthera sessilis can significantly ameliorate signs of hepatotoxicity in the CCl4 induced hepatotoxic rats.


Keywords: Alternanthera sessilis, Hepatotoxicity, Hepatic biomarkers.
Download this article as Download

How to cite this article:

Anurag Borthakur, Pritam Mohan, L.C. Lahon, D.J. Kalita, T. Rahman and Arup Sarmah. 2017. Evaluation of Hepatoprotective Property of Alternanthera sessilis in CCl4 Induced Hepatotoxicity in Rats.Int.J.Curr.Microbiol.App.Sci. 6(8): 3271-3279. doi: https://doi.org/10.20546/ijcmas.2017.608.390