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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(8): 3116-3122
DOI: https://doi.org/10.20546/ijcmas.2017.608.373


Wound Healing and Anti-Inflammatory Activity of Methanolic Extract of Gmelina arborea and Hemigraphis colorata in Rats
Bhagyalakshmi Chengattu Prakashbabu1, Deepthi Vijay1, Saju George1, Sameer Kodiyil1, Suresh Narayanan Nair1*, Ajithkumar Karaparambil Gopalan2, Sanis Juliet1 and Reghu Ravindran2
1Department of Veterinary Pharmacology and Toxicology,
2Department of Veterinary Parasitology, College of Veterinary and Animal Sciences,Pookode, Wayanad- Kerala-673576, India
*Corresponding author
Abstract:

Gmelina arborea and Hemigraphis colorata are traditionally used by tribal healers of Wayanad district, Kerala India. The wound healing and anti-inflammatory activity of Gmelina arborea and Hemigraphis coloratawere tested in adult wistar albino rats. Wound healing activity was assessed using excisional wound healing method and anti-inflammatory activity was assessed using carageenan induced paw oedema model. Acute oral toxicity of the extract was determined by giving the extract at the rate of 2000 mg/kg by single oral dose. For testing the wound healing activity, the methanolic extracts of the plants were used at 5% and 10% in paraffin vehicle and the effect was compared with the standard drug boric acid. Anti-inflammatory activity was assessed by single oral dose at the rate of 250 mg/kg and 500 mg/kg of the extracts subsequent to carageenan, keeping diclofenac as positive control. It was found that both plant extract did not possess any significant toxicity after oral dosing. H. colorata showed excellent wound healing activity and G. arborea showed moderate activity. With respect to the anti-inflammatory activity, G arborea was having better activity than H colorata extract, though both were significantly less effective than diclofenac. Both the plant extract showed significant wound healing as well as anti-inflammatory activities.


Keywords: Gmelina arborea, Hemigraphis colorata, Excisional wound healing, Carageenan induced paw oedema.
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How to cite this article:

Bhagyalakshmi Chengattu Prakashbabu, Deepthi Vijay, Saju George, Sameer Kodiyil, Suresh Narayanan Nair, Ajithkumar Karaparambil Gopalan, Sanis Juliet and Reghu Ravindran. 2017. Wound Healing and Anti-Inflammatory Activity of Methanolic Extract of Gmelina arborea and Hemigraphis colorata in Rats.Int.J.Curr.Microbiol.App.Sci. 6(8): 3116-3122. doi: https://doi.org/10.20546/ijcmas.2017.608.373