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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(8): 2857-2863
DOI: https://doi.org/10.20546/ijcmas.2017.608.341


Prevalence of Extended Spectrum Beta- Lactamase Producers among Various Clinical Samples in a Tertiary Care Hospital: Kurnool District, India
Suguneswari Giddi, Sarada Dasari* and C. Suryakumari
Department of Microbiology, Viswabharathi Medical College, Penchikalapadu, Kurnool District, A.P., India
*Corresponding author
Abstract:

Extended spectrum beta lactamase producers are posing a major obstacle in the therapeutic outcome of patients. They cause enzymatic hydrolysis of the beta lactum ring, resulting in resistance to penicillins and cephalosporins. The rise in ESBL producers results in prolonged treatment which leads to increased hospital stay and financial burden on the patient. It is necessary for all the hospitals to monitor ESBL producers to formulate preventive and therapeutic measures accordingly. The study was conducted in a tertiary care hospital during the period from December 2015 to November 2016. A total of 500 isolates from Enterobacteriaceae which included 400 Escherichia coli and 100 Klebsiella species isolates were processed. ESBL producers were detected by phenotypic screening and confirmatory methods which included double disc synergy method, Cephalosporin Clavulanate combination disc. Out of 400 Escherichia coli, 220 were ESBL producers (55%) and 34 out of Klebsiella species were ESBL producers (34%). Overall ESBL production was 50.8% and it was found to be higher in inpatients (55.67%) than outpatients (41.28%). All ESBL producers are 100% susceptible to Imipenem and Meropenem and maximum resistance to penicillin and cephalosporins (80-90%). ESBL producers pose threat in hospitals; their detection can be made mandatory along with routine antibiogram.


Keywords: ESBL producers, Escherichia coli, Klebsiella, Susceptibility pattern, Resistance pattern.
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How to cite this article:

Suguneswari Giddi, Sarada Dasari and Suryakumari, C. 2017. Prevalence of Extended Spectrum Beta- Lactamase Producers among Various Clinical Samples in a Tertiary Care Hospital: Kurnool District, IndiaInt.J.Curr.Microbiol.App.Sci. 6(8): 2857-2863. doi: https://doi.org/10.20546/ijcmas.2017.608.341