Follow
International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

Login as a Reviewer

Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

See Guidelines to Authors
Current Issues

Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(8): 2542-2551
DOI: https://doi.org/10.20546/ijcmas.2017.608.301


TH17/TH1 Role in Endocrine Disorders among Chronic HCV Infected Patients
Helal F. Hetta1*, Azza Elkady12 and Ahmed Kh Meshaal3
1Department of Medical Microbiology and Immunology, Faculty of Medicine,Assiut University, Assiut, Egypt
2Sohag General Hospital, Sohag University, Sohag, Egypt
3Department of Science, Al Azhar University, Assiut, Egypt
*Corresponding author
Abstract:

Since its discovery in 1989, hepatitis C virus (HCV) infection has become a major cause of chronic liver disease worldwide with 14.7% prevalence in Egypt. There is increasing body of evidence that chronic HCV infection is usually associated with several extrahepatic manifestations. Several studies have shed light on the association of autoimmune thyroiditis (ATD) and type 1 diabetes (T1D) with chronic HCV infection as both are considered to be one of the most common organ specific autoimmune disease frequently occur together. IL17 secreting helper T (Th17) and classic Th1 cells have been heavily implicated in mediating autoimmune endocrine diseases. However, plasticity within this subset is suggested by the existence of IL-17 secreting cells, which are able to secrete interferon-γ, the signature pro-inflammatory cytokine for Th1 cells which named non-classic Th1 cells. Here in this review we will summarize the most common organ-specific autoimmune disease associated with chronic hepatitis C infection. Also, we will focus on the role of Th1 and Th17 cells in initiating the autoimmune reaction.


Keywords: Th17, Th1, HCV, Endocrine disorders, Autoimmune disease.
Download this article as Download

How to cite this article:

Helal F. Hetta, Azza Elkady1 and Ahmed Kh Meshaal. 2017. TH17/TH1 Role in Endocrine Disorders among Chronic HCV Infected Patients.Int.J.Curr.Microbiol.App.Sci. 6(8): 2542-2551. doi: https://doi.org/10.20546/ijcmas.2017.608.301