National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Since its discovery in 1989, hepatitis C virus (HCV) infection has become a major cause of chronic liver disease worldwide with 14.7% prevalence in Egypt. There is increasing body of evidence that chronic HCV infection is usually associated with several extrahepatic manifestations. Several studies have shed light on the association of autoimmune thyroiditis (ATD) and type 1 diabetes (T1D) with chronic HCV infection as both are considered to be one of the most common organ specific autoimmune disease frequently occur together. IL17 secreting helper T (Th17) and classic Th1 cells have been heavily implicated in mediating autoimmune endocrine diseases. However, plasticity within this subset is suggested by the existence of IL-17 secreting cells, which are able to secrete interferon-γ, the signature pro-inflammatory cytokine for Th1 cells which named non-classic Th1 cells. Here in this review we will summarize the most common organ-specific autoimmune disease associated with chronic hepatitis C infection. Also, we will focus on the role of Th1 and Th17 cells in initiating the autoimmune reaction.
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