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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(8): 1255-1263
DOI: https://doi.org/10.20546/ijcmas.2017.608.152


Inquest of the SNP in Cystic Fibrosis – A Bioinformatic Approach
Balakrishnaraja Rengaraju1*, Keerthana1, Akila1, K. Pavithra1, D. Vinotha1, Sri Harsha Challapalli2 and Arunava Das1
1Bannari Amman Institute of Technology, Sathyamangalam-638401, India 2ETH Technical University, Zurich-8093, Switzerland
*Corresponding author
Abstract:

Single nucleotide polymorphisms or SNPs are DNA sequence variations occurring due to an alteration of a single nucleotide of the genome sequence. These variations have a major impact on human response to diseases and therapeutic drugs. Although SNPs may or may not cause a disease, they can help us to determine the probability of occurrence of the disease. One such well-known lethal genetic disorder is Cystic Fibrosis. It is an autosomal recessive disease caused by an alteration in the CFTR gene (Cystic Fibrosis Trans membrane conductance Regulator gene), which codes for a chloride channel protein, found in the membranes lining the respiratory and digestive tracts. Bearing some common symptoms is the disorder chronic rhino sinusitis, which can also be traced to the alteration in the same CFTR gene. A comparative study of the two diseases indicates that the former requires two copies of the altered gene whereas a single copy may influence the occurrence of the latter. Our SNP analysis of this gene reveals that a point mutation occurs at locus 5618 of the nucleotide sequence leading to the conversion of the amino acid histidine to proline thus affecting the three-dimensional structure of the protein.


Keywords: SNP, CFTR gene, Cystic fibrosis, BLAST, SWISSPROT.
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How to cite this article:

Balakrishnaraja Rengaraju, Keerthana, Akila, K. Pavithra, D. Vinotha, Sri Harsha Challapalli and Arunava Das. 2017. Inquest of the SNP in Cystic Fibrosis – A Bioinformatic Approach.Int.J.Curr.Microbiol.App.Sci. 6(8): 1255-1263. doi: https://doi.org/10.20546/ijcmas.2017.608.152