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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(7): 4305-4309
DOI: https://doi.org/10.20546/ijcmas.2017.607.447


Effect of Hemidesmus indicus Extract against Methcillin Resistant taphylococcus aureus from Various Clinical Specimens
Vignesh Kanna1, E. Kavitha2, M. Swapna2 and Joshy M. Easow3*
1Department of Microbiology, Annapoorana medical College and Hospital, Salem, India
2Department of Microbiology, Sri Venkateshwaraa Medical College, Hospital and Research centre, Pondicherry, India
3Nirmal lab, Pondicherry, India
*Corresponding author
Abstract:

Methicillin Resistant Staphylococcus aureus (MRSA) strains represent a worldwide threat because of their virulence and broad distribution in the hospital settings and community. MRSA strains are often resistant to beta lactam antibiotics and also to flouroquinolones, chloramphenicol, clindamycin, tetracycline and aminoglycosides. In addition, resistance is shown to recently develop anti-staphylococcus agents including the Oxazolidione and Streptogramin. Increasing in multi-drug resistant strains there is a need of alternative source. Bioactive compounds from natural products and traditional medicinal plants show promising role in treatment to control MRSA infection. We aimed to report the anti MRSA activity of ethanolic extract of Hemidesmus indicus root and its possible interaction with antibiotics. A total of 100 MRSA isolates from various clinical samples were included in the study. Ethanolic root extract of Hemidesmus indicus was done by using soxhlet apparatus. These isolates were subjected to perform antimicrobial susceptibility testing by Well-diffusion method, MIC and synergistic interaction with antibiotics. In this study for the concentration of 50µl shows 25% were sensitive and 75% were resistant. At 100µl 61% were sensitive and 39% were resistant. For MIC ranging from 6.20 to 10.65mg, 70% shows sensitive and 30% were resistant. Doxycycline, ciprofloxacin and amikacin 61%, 45%, 40% were showed synergism respectively.


Keywords: Hemidesmus indicus, MRSA, MIC.
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How to cite this article:

Vignesh Kanna, B., E. Kavitha, M. Swapna and Joshy M. Easow. 2017. Effect of Hemidesmus indicus Extract against Methcillin Resistant Staphylococcus aureus from Various Clinical Specimens.Int.J.Curr.Microbiol.App.Sci. 6(7): 4305-4309. doi: https://doi.org/10.20546/ijcmas.2017.607.447