National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Methicillin Resistant Staphylococcus aureus (MRSA) strains represent a worldwide threat because of their virulence and broad distribution in the hospital settings and community. MRSA strains are often resistant to beta lactam antibiotics and also to flouroquinolones, chloramphenicol, clindamycin, tetracycline and aminoglycosides. In addition, resistance is shown to recently develop anti-staphylococcus agents including the Oxazolidione and Streptogramin. Increasing in multi-drug resistant strains there is a need of alternative source. Bioactive compounds from natural products and traditional medicinal plants show promising role in treatment to control MRSA infection. We aimed to report the anti MRSA activity of ethanolic extract of Hemidesmus indicus root and its possible interaction with antibiotics. A total of 100 MRSA isolates from various clinical samples were included in the study. Ethanolic root extract of Hemidesmus indicus was done by using soxhlet apparatus. These isolates were subjected to perform antimicrobial susceptibility testing by Well-diffusion method, MIC and synergistic interaction with antibiotics. In this study for the concentration of 50µl shows 25% were sensitive and 75% were resistant. At 100µl 61% were sensitive and 39% were resistant. For MIC ranging from 6.20 to 10.65mg, 70% shows sensitive and 30% were resistant. Doxycycline, ciprofloxacin and amikacin 61%, 45%, 40% were showed synergism respectively.
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