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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(1): 364-375
DOI: http://dx.doi.org/10.20546/ijcmas.2016.501.034


Synthesis and Evaluation of Ethyl 2-(2-Cyano-3-(Substituted Phenyl) Acrylamido)-4,5,6,7-Tetrahydrobenzo[b]Thiophene-3-Carboxylates for Antioxidant and Antibacterial Activities
K. Madhavi and K. V. Ramanamma
Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visvav
*Corresponding author
Abstract:

A series of ethyl 2-(2-cyano-3-(substituted phenyl)acrylamido)-4,5,6,7- tetrahydrobenzo[b]thiophene-3-carboxylates were prepared by knoevenagel condensation of active methylene group of ethyl 2-(2-cyanoacetamido)- 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate with substituted benzaldehydes in toluene containing catalytic amounts of glacial acetic acid and piperidine. All the compounds were purified by recrystallization from suitable solvent and characterized by spectral and analytical methods. The antioxidant properties and antibacterial effects of the synthesized compounds were studied. Among the series, compounds with 4-hydroxy substituent on phenyl ring exhibited greater antioxidant activity at 100 µM concentration. The results of antibacterial activity revealed that 4-dimethyl amino derivative exhibited highest activity against B. subtilis, E.coli and S. aureus.


Keywords: Substituted 2- aminothiophenes, Substituted benzaldehydes, Knoevenagel condensation.
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How to cite this article:

 Int.J.Curr.Microbiol.App.Sci. 5(1): 364-375. doi: http://dx.doi.org/10.20546/ijcmas.2016.501.034