National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The protective effect of quercetin on doxorubicin induced testicular tissue damage was investigated using histopathological and ultra structural pathology approaches. A total of 48 male albino rats (Wistarstrain) were randomly divided into 4 groups consisting of 12 in each group. Group 1-Control, Group 2-Doxorubicin treated @4mg/kg b.wt intraperitoneally weekly once. Group 3-treated with quercetin @ 80mg/kgb.wt, orally daily. Group 4-treated with doxorubicin @ 4 mg/kg b.wt, intraperitoneally weekly once and quercetin @ 80mg/kg b.wt, orally daily. The histopathological studies of group 2 showed loss of germ cells with vacuolation in semniferous tubules, coagulative type of necrosis and edema in the interstitial spaces. In later stages severe atrophy of semniferous tubules with loss of germ cells and giant cells were noticed. In group 4 spermatogenesis with several mitotic figures along with mild degenerative changes were noticed. The ultra-structural-studies of group 2 revealed margination of chromatin, swelling of mitochondria and vacuolar changes in cell cytoplasm and on 29th severity was increased with complete loss of cell integrity. In group 4 improvement was noticed with appearance of germ cells and sperm cells.
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