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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(7): 2295-2306
DOI: https://doi.org/10.20546/ijcmas.2017.607.330


Pathological and Ultra-structural Changes in Testis of Rats due to Doxorubicin Toxicity and its Amelioration with Quercetin
S. Divya1, D. Madhuri1*, M. Lakshman1 and A. Gopal Reddy2
1Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad-500030, Telangana, India
2Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad-500030, Telangana, India
*Corresponding author
Abstract:

The protective effect of quercetin on doxorubicin induced testicular tissue damage was investigated using histopathological and ultra structural pathology approaches. A total of 48 male albino rats (Wistarstrain) were randomly divided into 4 groups consisting of 12 in each group. Group 1-Control, Group 2-Doxorubicin treated @4mg/kg b.wt intraperitoneally weekly once. Group 3-treated with quercetin @ 80mg/kgb.wt, orally daily. Group 4-treated with doxorubicin @ 4 mg/kg b.wt, intraperitoneally weekly once and quercetin @ 80mg/kg b.wt, orally daily. The histopathological studies of group 2 showed loss of germ cells with vacuolation in semniferous tubules, coagulative type of necrosis and edema in the interstitial spaces. In later stages severe atrophy of semniferous tubules with loss of germ cells and giant cells were noticed. In group 4 spermatogenesis with several mitotic figures along with mild degenerative changes were noticed. The ultra-structural-studies of group 2 revealed margination of chromatin, swelling of mitochondria and vacuolar changes in cell cytoplasm and on 29th severity was increased with complete loss of cell integrity. In group 4 improvement was noticed with appearance of germ cells and sperm cells.


Keywords: Rats, Testis, Doxorubicin, Quercetin, Histopathology and ultrastructural pathology
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How to cite this article:

Divya, S., D. Madhuri, M. Lakshman and Gopal Reddy, A. 2017. Pathological and Ultra-structural Changes in Testis of Rats due to Doxorubicin Toxicity and its Amelioration with Quercetin.Int.J.Curr.Microbiol.App.Sci. 6(7): 2295-2306. doi: https://doi.org/10.20546/ijcmas.2017.607.330