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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(7): 2194-2199
DOI: https://doi.org/10.20546/ijcmas.2017.607.318


Carbapenems Resistance Klebsiella Species Isolated from Various Clinical Samples in a Tertiary Care Hospital
Rajeswari Jayakumar*, Vijayalakshmi Arumugam and Meerah Srinivasagam
Department of Microbiology, Chengalpattu Medical College, Chengalpattu, Kancheepuram District, Tamilnadu, India
*Corresponding author
Abstract:

Carbapenems are one of the β-Lactam antibiotics with a broad spectrum of antibacterial activity. Inappropriate use of this antibiotic can produce resistance strains by production of carbapenemases enzyme. The Klebsiella pneumoniae carbapenemase (KPC) is the most important mechanism of enzymatic resistance seen in Enterobacteriaceae isolated especially Klebsiella pneumoniae. The aim and objectives of this study was isolation and detection of the Carbapenem resistant Klebsiella species strains with phenotypic methods. Out of 11248 samples, 602 Klebsiella species (33.7%), were isolated by standard Microbiological protocol & Antibiotic susceptibility test was performed by disk diffusion method with CLSI guidelines. A total 602 Klebsiella species strains were isolated. Of the 602 isolates of Klebsiella species, Klebsiella pneumoniae were 323 (54%) and Klebsiella oxytoca were 279 (46%). Antibiotic sensitivity pattern revealed maximum resistant to Cephalosporins (22%) followed by Ciproflaxacin (14%), Gentamycin (10%), Ceftriaxone -Clavulanate (8%), Piperacillin- Taxobactum (7%), Amikacin (7%).Out of 602 Klebsiella spp, Carbapenems resistant isolates were 28 (5%).All the 28 (100%) isolates were resistant to Meropenem and 23 (83%) isolates were resistant to Imipenem. Carbapenems are the drug of choice for multidrug resistant infections, like ESBL and AmpC producing isolates, but resistance to carbapenems by the production of carbapenamases and various other mechanisms has limited therapeutic options to use carbapenem drugs.


Keywords: Klebsiella pneumoniae, Carbapenem Resistance.
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How to cite this article:

Rajeswari Jayakumar, Vijayalakshmi Arumugam and Meerah Srinivasagam. 2017. Carbapenems Resistance Klebsiella Species Isolated from Various Clinical Samples in a Tertiary Care Hospital.Int.J.Curr.Microbiol.App.Sci. 6(7): 2194-2199. doi: https://doi.org/10.20546/ijcmas.2017.607.318