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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(4): 193-201
DOI: http://dx.doi.org/10.20546/ijcmas.2016.504.024


Antiulcer Activity of Morinda citrifolia Linn. Root Extracts
Vijay Dnyandeo Tambe1* and Rajendra Sudhakar Bhambar2
1Department of Pharmacognosy, Pravara Rural College of Pharmacy, A/P-Loni,Tal-Rahata, Dist-Ahmednagar-413 736 Maharashtra, India
2Department of Pharmacognosy, MGV’S College of Pharmacy, Panchvati, Nasik,
Maharashtra, India
*Corresponding author
Abstract:

The present study was performed in order to investigate the antiulcer activity of different extracts of the root of Morinda citrifolia Linn (Rubiaceae) using different models of gastric and duodenal ulceration in rats. Gastric ulcers were induced by oral administration of ethanol, aspirin and by pyloric ligation while the duodenal ulcers were induced by oral administration of cysteamine hydrochloride. The extracts were administered at a dose of 200 and 400 mg/kg orally 30 minutes prior to ulcer induction. Ranitidine (50 mg/kg) was used as a reference standard.  The antiulcer activity was accessed by determining and comparing the ulcer index in the test group with that of the standard drug treated group. Gastric volume, total acid and free acid were estimated in the pylorus-ligated rats. M. citrifolia (400 mg/kg) showed maximum inhibition of gastric acid, free acid and total acid to 52.23%, 55.23% and 29.11% respectively. The ulcer index in the M. citrifolia treated animals was found to be significantly less in all the models compared to standard drug treated cases. The antiulcer activity of extracts was however less than that of standard drug ranitidine. The results suggest that the roots of M. citrifolia possesses significant antiulcer property which could be due to cytoprotective action of the drug or strengthening of gastric and duodenal mucosa with the enhancement of mucosal defense.


Keywords: Morinda citrifolia, Antiulcer, root,Cysteamine hydrochloride, Ranitidine.
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How to cite this article:

Vijay Dnyandeo Tambe and Rajendra Sudhakar Bhambar. 2016. Antiulcer Activity of Morinda citrifolia Linn. Root ExtractsInt.J.Curr.Microbiol.App.Sci. 5(4): 193-201. doi: http://dx.doi.org/10.20546/ijcmas.2016.504.024