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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(7): 1193-1209
DOI: https://doi.org/10.20546/ijcmas.2017.607.145


Hypoglycemic Efficacy of Catharanthus roseus and Opuntia ficusindica in Mice Diabetic Model
Shilpi Jaya and Baidyanath Kumar*
Department of Biotechnology, College of Commerce, Arts and Science Patna-800020, India
*Corresponding author
Abstract:

Diabetes mellitus (DM) is a metabolic disorder of multiple etiologies characterized by absolute or relative deficiency of insulin secretion with or without varying degree of insulin resistance. Sedentary life style and obesity are two major epidemiological determinants of diabetes mellitus. In the present investigation hypoglycemic efficacy of methanol extract of Catharanthus roseus (Nayantara) of Apocyanaceae and Opuntia ficusindica of Cactaceae was tested on STZ induced mice diabetic models. The results clearly indicated that the diabetic control (DC) mice presented a significant lowering of body weight (p<0.001) when compared with the normal control (NC) mice. The DC mice showed a significantly (p<0.001) higher level of glucose (+279%), when compared with their normal control counterparts. Diabetic mice of both of the groups (DT150 and DT250) showed a reduction in glucose levels, when compared to the DC ones. The results clearly indicated that the methanol extract of C. roseus and O. ficusindica is antidiabetic in nature due to the presence of different types of active phytochemicals.


Keywords: Diabetes mellitus, Catharanthus roseus, Opuntia ficusindica, Streptozotocin, Mice.
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How to cite this article:

Shilpi Jaya and Baidyanath Kumar. 2017. Hypoglycemic Efficacy of Catharanthus roseus and Opuntia ficusindica in Mice Diabetic Model.Int.J.Curr.Microbiol.App.Sci. 6(7): 1193-1209. doi: https://doi.org/10.20546/ijcmas.2017.607.145