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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(6): 1733-1739
DOI: https://doi.org/10.20546/ijcmas.2017.606.201


Hematological Changes in Severe P. falciparum Malaria
Bidyut Prava Das1*, Ratnadeep Ganguly1, Hemant Kumar Khuntia2, Madhusmita Bal2 and Manoranjan Ranjit2
1Department of Pathology, SCB Medical College and Hospital, Cuttack, India
2ICMR-Regional Medical Research Centre, Chandrasekharpur, Bhubaneswar, India
*Corresponding author
Abstract:

Hematological changes are among the most common complications encountered in malaria. This study analyzes and statistically evaluates the hematological changes occur in complicated malaria as compared to uncomplicated malaria. The present study was conducted from January to December 2012 in SCB Medical College, Cutack of Odisha. A total of 120 severe/ complicated malaria patients and 80 uncomplicated malaria patients were investigated. The complicated malaria cases had significantly low level of Hb level as compared to uncomplicated cases (P<0.05). Hyperparasitemia (>250000/µl) was found in 25 cases, leukocytosis (>10 x 109 /L) in 34 cases, leukopenia (<4x109 /L) in 18 cases, thrombocytopenia (< 60 X 10 9 /L) in 34 cases and overt bleeding was observed in 54 cases having complicated malaria. Atypical lymphocytes were present in 4 cases while at least 36 of cases had malarial pigment in monocytes and 4 cases in neutrophil. The patients having complicated malaria had significantly low platelet count compared to uncomplicated malaria. Around 79.63% cases showed a significantly high level of PPT and 53.70% with high aPTT (p<0.05) than uncomplicated cases. The increased plasma d-DIMER level was significantly high in complicated cases as compared to uncomplicated cases (40%). This study revealed that routinely used haematological findings such as hemoglobin, hyperparasitemia, thermbocytopenia, platelet count, PPT level, aPPT and d-DIMER can be considered as prognostic marker for severe/ complicated malaria in endemic areas


Keywords: Hematological, P. falciparum, Lymphocytes, Complicated malaria
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How to cite this article:

Bidyut Prava Das, Ratnadeep Ganguly, Hemant Kumar Khuntia, Madhusmita Bal and Manoranjan Ranjit. 2017. Hematological Changes in Severe P. falciparum Malaria.Int.J.Curr.Microbiol.App.Sci. 6(6): 1733-1739. doi: https://doi.org/10.20546/ijcmas.2017.606.201