National Academy of Agricultural Sciences (NAAS)
|
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
In a retrospective study, conducted in Chennai (India), during 2005, a total of 104 bacterial isolates, obtained from 75 diabetic foot ulcer patients, revealed the presence of 9-bacterial species, namely, S.aureus, CONS spp, Streptococcus spp, Corynebacterium spp, Enterococcus spp, E.coli, Klebsiella spp, Proteus spp, and P.aeruginosa, in different percentages. The in-vitro antibiotic sensitivity pattern of Pseudomonas aeruginosa, tested in the retrospective study, and the antibiotic sensitivity patterns of the 8-other pathogens as adopted from available literature relating to 2-South Indian locations (Kelambakkam and Bengaluru), and 2-North Indian locations (Chandigarh and New Delhi), were compared with the data of the multicentre trial studies related to diabetic foot infections, carried out by Citron, D.M., et al., (2007), in the United States. There was a close agreement among the AMAs evaluated, in the case of all the 9-pathogens, in the antimicrobial susceptibility range of 100.0% to 66.7% (bacterial resistance range of 0.0% to 33.3%). A hypothetical estimate of drug-burden was made, by enlisting the number of AMAs needed to be administered on a patient, against the 9-pathogens, in order to obtain a cure. A discussion on the probable adverse reactions caused by AMAs is included. It is suggested that AMAs such as Ertapenem, Trimethoprim/sulfamethxazole, Tigecycline, Doxycycline, etc, tested in the United States, can be included in evaluating the antibiotic susceptibility patterns, in India. Such results, if generated, would be found useful when the currently-used AMAs happen to become ineffective due to bacterial resistance, in future. More number of AMAs, if tested, would make it easier to optimize on the choice of drugs.
Citations |
 |
 |
 |
 |
