Follow
International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

Login as a Reviewer

Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

See Guidelines to Authors
Current Issues

Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(6): 1139-1153
DOI: https://doi.org/10.20546/ijcmas.2017.606.132


Hypothetical Estimate of Drug-Burden on a Diabetic Foot Ulcer Patient and its Relevance to Microbiological Analysis
C. Meenakshisundaram1*, J. Uma Rani2, Usha Anand Rao2, V. Mohan3 and R. Vasudevan3
1Department of Microbiology, Sri Venkateswara Medical College and Research Centre, Pondicherry-605 102, India
2Department of Microbiology, Dr. A.L.M. Post-Graduate Institute of Basic Medical Sciences, Tharamani Campus, University of Madras, Chennai-600 013, India
3Dr.Mohan’s Diabetic Specialties Research Centre, Gopalapuram, Chennai-600 028, India
*Corresponding author
Abstract:

In a retrospective study, conducted in Chennai (India), during 2005, a total of 104 bacterial isolates, obtained from 75 diabetic foot ulcer patients, revealed the presence of 9-bacterial species, namely, S.aureus, CONS spp, Streptococcus spp, Corynebacterium spp, Enterococcus spp, E.coli, Klebsiella spp, Proteus spp, and P.aeruginosa, in different percentages. The in-vitro antibiotic sensitivity pattern of Pseudomonas aeruginosa, tested in the retrospective study, and the antibiotic sensitivity patterns of the 8-other pathogens as adopted from available literature relating to 2-South Indian locations (Kelambakkam and Bengaluru), and 2-North Indian locations (Chandigarh and New Delhi), were compared with the data of the multicentre trial studies related to diabetic foot infections, carried out by Citron, D.M., et al., (2007), in the United States. There was a close agreement among the AMAs evaluated, in the case of all the 9-pathogens, in the antimicrobial susceptibility range of 100.0% to 66.7% (bacterial resistance range of 0.0% to 33.3%). A hypothetical estimate of drug-burden was made, by enlisting the number of AMAs needed to be administered on a patient, against the 9-pathogens, in order to obtain a cure. A discussion on the probable adverse reactions caused by AMAs is included. It is suggested that AMAs such as Ertapenem, Trimethoprim/sulfamethxazole, Tigecycline, Doxycycline, etc, tested in the United States, can be included in evaluating the antibiotic susceptibility patterns, in India. Such results, if generated, would be found useful when the currently-used AMAs happen to become ineffective due to bacterial resistance, in future. More number of AMAs, if tested, would make it easier to optimize on the choice of drugs.


Keywords: Drug burden, Diabetic foot ulcer patients Optimization of antimicrobial agents.
Download this article as Download

How to cite this article:

Meenakshisundaram, C., J. Uma Rani, Usha Anand Rao, V. Mohan and Vasudevan, R. 2017. Hypothetical Estimate of Drug-Burden on a Diabetic Foot Ulcer Patient, and Its Relevance to Microbiological Analysis.Int.J.Curr.Microbiol.App.Sci. 6(6): 1139-1153. doi: https://doi.org/10.20546/ijcmas.2017.606.132