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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(3): 277-287
DOI: http://dx.doi.org/10.20546/ijcmas.2016.503.034


Role of HLA DQ Genotyping with Some Immunological Markers in Susceptibility for Infertile Males in Najaf Province
Hammadi A. Al-Hilali* and Haider J. Al-hasani
Department of Medical Microbiology, Faculty of Medicine, Al-Qadisiya University, Diwaniya, Iraq
*Corresponding author
Abstract:

Infertility may be defined as the infertility of a couple to conceive after a period of one year of intercourse without use of contraceptive. It is a worldwide problem that characterized by multifactorial etiology. Genetic, physiology, infectious, environmental factors and autoimmunity are reported as for as predisposal or even causative agents of this condition. The current study has the aim of evaluation of some immunological markers level and HLA DQB1 genotyping roles among infertile male's patients. We have investigated HLA DQB1 HISTOSPOT in 75 subjects by using. Fifty were infertile patients while others were apparently healthy individuals used as a controls, then the serum level of IL6 and ASA was measure in seminal plasma, were detected by ELISA technique and ANA was detected in sera using indirect immune fluorecent assay test. The frequencies of *0303 allele a clear difference between Azospermia and control groups, these differences are significant (probability = 0.018), while in the oligospermia patients with DQB1 *0305 allele duplicates high compared to control and that the difference significant (probability = 0.074). The study conclude that the (ASA, IL-6) and the presence in the semen are signs of increase of patients with infertility, as well as the presence of alleles DQB1 *0303 and DQB1 *0305 increases the probability of non-production of sperm and decrease it in the count respectively.


Keywords: Infertility, ASA, ANA, IL6, Allele, Genotype, MR SPOT, HLA DQB1.
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How to cite this article:

Hammadi A. Al-Hilali and Haider J. Al-hasani. 2016. Role of HLA DQ Genotyping with Some Immunological Markers in Susceptibility for Infertile Males in Najaf Province. Int.J.Curr.Microbiol.App.Sci. 5(3): 277-287. doi: http://dx.doi.org/10.20546/ijcmas.2016.503.034