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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:3, March, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(3): 785-791
DOI: http://dx.doi.org/10.20546/ijcmas.2016.503.091


Synthesis, Characterization and Antimicrobial Screening of Novel Ortho Hydroxy Chalcones
 Abdulkareem Ali Hussien1,2*, Bushra Ahmed Kateb1,2, Shekh Saddam Husen3 and P. A. Kulkarni1
1Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431602 (MS), India
2Hodiedah University, Education College, Yemen
3Swami Ramanand Teerth University, Nanded, India
*Corresponding author
Abstract:

New series of chalcones(1a-j) were synthesized by Claisen-Schmidt condensation of 2-hydroxy, 5-methyl acetophenone with several aromatic aldehydes in presence of aqueous solution of sodium hydroxide.The synthesized chalcones compounds were characterized by Physical and spectral methods such as melting point, IR, 1H-NMR and Mass analysis. All the synthesized compounds have been screened and evaluated for antibacterial activity against Staphylococcus aureus gr +ve, Escherichia coli gr –ve Bacillus subtilis gr +ve, Salmonella typhi gr –ve, and antifungal activity against Aspergillus oryzoe, Aspergillus niger. DMSO was used as solvent control for their antimicrobial activity using disc diffusion method. Synthesis and biological evaluation of chalcones have been a topic of special interest to organic and medicinal chemists. The new structural classes of compounds may prove as lead molecules and good candidates for the future investigations.


Keywords: Chalcones, Claisen-Schmidt condensation, Characterization, Antimicrobial activities.

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How to cite this article:

Abdulkareem Ali Hussien, Bushra Ahmed Kateb, Shekh Saddam Husen and Kulkarni, P. A. 2016. Synthesis, Characterization and Antimicrobial Screening of Novel Ortho Hydroxy Chalcones.Int.J.Curr.Microbiol.App.Sci. 5(3): 785-791. doi: http://dx.doi.org/10.20546/ijcmas.2016.503.091
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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