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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
New series of chalcones(1a-j) were synthesized by Claisen-Schmidt condensation of 2-hydroxy, 5-methyl acetophenone with several aromatic aldehydes in presence of aqueous solution of sodium hydroxide.The synthesized chalcones compounds were characterized by Physical and spectral methods such as melting point, IR, 1H-NMR and Mass analysis. All the synthesized compounds have been screened and evaluated for antibacterial activity against Staphylococcus aureus gr +ve, Escherichia coli gr –ve Bacillus subtilis gr +ve, Salmonella typhi gr –ve, and antifungal activity against Aspergillus oryzoe, Aspergillus niger. DMSO was used as solvent control for their antimicrobial activity using disc diffusion method. Synthesis and biological evaluation of chalcones have been a topic of special interest to organic and medicinal chemists. The new structural classes of compounds may prove as lead molecules and good candidates for the future investigations.