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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(3): 785-791
DOI: http://dx.doi.org/10.20546/ijcmas.2016.503.091


Synthesis, Characterization and Antimicrobial Screening of Novel Ortho Hydroxy Chalcones
 Abdulkareem Ali Hussien1,2*, Bushra Ahmed Kateb1,2, Shekh Saddam Husen3 and P. A. Kulkarni1
1Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431602 (MS), India
2Hodiedah University, Education College, Yemen
3Swami Ramanand Teerth University, Nanded, India
*Corresponding author
Abstract:

New series of chalcones(1a-j) were synthesized by Claisen-Schmidt condensation of 2-hydroxy, 5-methyl acetophenone with several aromatic aldehydes in presence of aqueous solution of sodium hydroxide.The synthesized chalcones compounds were characterized by Physical and spectral methods such as melting point, IR, 1H-NMR and Mass analysis. All the synthesized compounds have been screened and evaluated for antibacterial activity against Staphylococcus aureus gr +ve, Escherichia coli gr –ve Bacillus subtilis gr +ve, Salmonella typhi gr –ve, and antifungal activity against Aspergillus oryzoe, Aspergillus niger. DMSO was used as solvent control for their antimicrobial activity using disc diffusion method. Synthesis and biological evaluation of chalcones have been a topic of special interest to organic and medicinal chemists. The new structural classes of compounds may prove as lead molecules and good candidates for the future investigations.


Keywords: Chalcones, Claisen-Schmidt condensation, Characterization, Antimicrobial activities.
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How to cite this article:

Abdulkareem Ali Hussien, Bushra Ahmed Kateb, Shekh Saddam Husen and Kulkarni, P. A. 2016. Synthesis, Characterization and Antimicrobial Screening of Novel Ortho Hydroxy Chalcones.Int.J.Curr.Microbiol.App.Sci. 5(3): 785-791. doi: http://dx.doi.org/10.20546/ijcmas.2016.503.091