National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Transcription factors (TFs) are DNA-binding proteins responsible for initiating transcription of particular genes upon interacting with specific DNA sequences located in their promoter or enhancer regions. Most of the transcription factors act as dimers (homodimer or heterodimer) or as higher order multimers. Therefore, it is useful to investigate associated structural and functional relationship between TFs and transcription factor binding sites (TFBSs). With increasing computational power, massive experimental databases available for DNA and proteins and recent data mining techniques, it becomes feasible to study the phylogenetic relationship between TFs and TFBSs. In the present study, we have made a framework to predict the evolutionary relationship between TFs and TFBSs patterns in the most explicit and interpretable form using JASPAR and Phylogeny.fr. We have collected 20 human TFBSs from JASPAR database. We have constructed and analysed phylogenetic relationships between TFBS using Phylogeny.fr web service, and conclude that specific domain (α-helix) of nearly all transcription factor families interact in a same way to regulate gene expression pattern. We propose that transcription factors interact in different ways to regulate the expression of different pathways and are phylogenetic ally related, they may have evolved from common ancestor indicating functional divergence.
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