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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(6): 776-785
DOI: https://doi.org/10.20546/ijcmas.2017.606.091


Few selected Human Transcription Factors Sequence Analysis and their Phylogenetic Relationship
Karmveer Yadav*
Department of Biochemistry, University of Hyderabad, Hyderabad, 500046, India
*Corresponding author
Abstract:

Transcription factors (TFs) are DNA-binding proteins responsible for initiating transcription of particular genes upon interacting with specific DNA sequences located in their promoter or enhancer regions. Most of the transcription factors act as dimers (homodimer or heterodimer) or as higher order multimers. Therefore, it is useful to investigate associated structural and functional relationship between TFs and transcription factor binding sites (TFBSs). With increasing computational power, massive experimental databases available for DNA and proteins and recent data mining techniques, it becomes feasible to study the phylogenetic relationship between TFs and TFBSs. In the present study, we have made a framework to predict the evolutionary relationship between TFs and TFBSs patterns in the most explicit and interpretable form using JASPAR and Phylogeny.fr. We have collected 20 human TFBSs from JASPAR database. We have constructed and analysed phylogenetic relationships between TFBS using Phylogeny.fr web service, and conclude that specific domain (α-helix) of nearly all transcription factor families interact in a same way to regulate gene expression pattern. We propose that transcription factors interact in different ways to regulate the expression of different pathways and are phylogenetic ally related, they may have evolved from common ancestor indicating functional divergence.


Keywords: Human transcription, DNA, Proteins, Phylogenetic relationship.
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How to cite this article:

Karmveer Yadav. 2017. Few Selected Human Transcription Factors Sequence Analysis and their Phylogenetic RelationshipInt.J.Curr.Microbiol.App.Sci. 6(6): 776-785. doi: https://doi.org/10.20546/ijcmas.2017.606.091