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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(3): 776-786
DOI: http://dx.doi.org/10.20546/ijcmas.2016.503.090


Multiple Micronutrient Supplementation Effect on Vital Metabolic parameters of Stable HIV Patients on Long term Highly Active Antiretroviral Therapy; A Randomized Crossover Trial
Anthony C. Iwu1, Kenechi A. Uwakwe2, Chukwuma B. Duru2*, Kevin C. Diwe2, Irene A. Merenu2, Abah O. Steve4, Christopher N. Obionu3, Nathan C. Nwaimo5, Uche R. Oluoha1, Ikechi Ohanle1 and Emmanuel U. Ndukwu1
1Department of Community Medicine, Imo State University Teaching Hospital, Orlu Imo State, Nigeria
2Department of Community Medicine, Imo State University, Owerri, Imo State, Nigeria

3College of Medicine, University of Nigeria Nsukka, Enugu State, Nigeria
4College of Medicine, Ambrose Ali University Ekpoma, Edo Nigeria
5Department of Chemical Pathology, Imo State University Teaching Hospital, Orlu Imo State, Nigeria
*Corresponding author
Abstract:

The effective and widespread use of Highly Active Antiretroviral Therapy (HAART) has resulted in people with Human Immunodeficiency Virus (HIV) infection now living longer especially in resource limited regions with non AIDS defining diseases becoming a major cause of illness and management concern in patients on long term HAART. To determine the effect of multiple micronutrient supplementation on the vital metabolic parameters of clinically stable HIV patients on long term HAART. A randomized crossover intervention trial was used to determine the effect of a 12 week daily consumption of multiple micronutrient supplements on 50 clinically stable HIV infected clients receiving treatment from the Imo State University Teaching Hospital. The participants were purposively selected based on certain inclusion criteria and were randomized into two groups to receive the supplement at different periods after a washout period. The measurements of the levels of the metabolic parameters were taken at baseline, 12, 20 and 32 weeks. The mean age of the participants studied was 43.8±10.8 years with an average duration on HAART of 3.2±1.5 years. At baseline, 55.3% of the participants were severely immunodeficient, 51.1% were either overweight or obese, 45% were hypertensive and 57.4%, 55.3%, 80.9% and 68.1% respectively had high serum urea, albumin and liver enzymes. The intervention result, revealed that there was no statistically significant difference in the levels of the vital metabolic parameters with micronutrient supplementation compared to no supplementation. Micronutrient supplementation in HIV patients on long term HAART appear not to have any significant effect on the vital metabolic parameters.


Keywords: Micronutrient Supplementation, Vital metabolic parameters, HIV patients, HAART.
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How to cite this article:

Anthony C. Iwu, Kenechi A. Uwakw, Chukwuma B. Dur, Kevin C. Diwe, Irene A. Meren, Abah O. Steve, Christopher N. Obionu, Nathan C. Nwaimo, Uche R. Oluoha, Ikechi Ohanle and Emmanuel U. Ndukwu. 2016. Multiple Micronutrient Supplementation Effect on Vital Metabolic parameters of Stable HIV Patients on Long term Highly Active Antiretroviral Therapy; A Randomized Crossover Trial.Int.J.Curr.Microbiol.App.Sci. 5(3): 776-786. doi: http://dx.doi.org/10.20546/ijcmas.2016.503.090