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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(6): 313-327
DOI: https://doi.org/10.20546/ijcmas.2017.606.038


Occult Hepatitis C Infection and its Clinical Relevance in Lymphoproliferative Disorders
Salah Agha, Noha El-Mashad* and Mohamed Mofreh
Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Egypt
*Corresponding author
Abstract:

Chronic hepatitis C virus (HCV) infection remains a global health threat with 175 million carriers worldwide. Approximately 3% of the worldwide population is infected with the hepatitis C virus (HCV). Lymphoproliferative disorder (LPD) is a term that includes a wide spectrum of pathologies ranging from a minor expansion of a B-cell population (with no clinical significance) to an aggressive high-grade lymphoma. Such proliferations of B cells apparently can be triggered as a consequence of a chronic antigenic stimulation resulting from an HCV infection. A causative association between hepatotropic viruses, especially hepatitis C virus, and malignant B-cell lymphoproliferative disorders has been demonstrated utilizing epidemiologic data, biologic and molecular investigations, as well as clinical observations. These data indicate that hepatitis C virus may be responsible for the development of some malignant lymphoproliferative disorders. Occult hepatitis C virus infection (OCI) was first reported by Pham et al., (2004) who examined the expression of the HCV genome in the sera, PBMC, using a highly sensitive reverse transcription (RT)-PCR-nucleic acid hybridization (RT-PCR-NAH) assay. Occult hepatitis C virus infection (OCI), defined as the presence of HCV RNA in the liver and peripheral blood mononuclear cells (PBMCs) in the absence of detectable viral RNA in serum by standard assays. It can be found in both anti-HCV positive and negative cases.


Keywords: Hepatotropic, Lynohproliferative, Population, RNA, Hepatitis C virus
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How to cite this article:

Salah Agha, Noha El-Mashad and Mohamed Mofreh. 2017. Occult Hepatitis C Infection and its Clinical Relevance in Lymphoproliferative Disorders.Int.J.Curr.Microbiol.App.Sci. 6(6): 313-327. doi: https://doi.org/10.20546/ijcmas.2017.606.038