Staphylococcus aureus recently shows resistance to many Beta lactam antibiotics and Carbapenems. This study is focused on the incidence of MRSA in NICUs. Using Gram staining, blood culture and antibiotic sensitivity tests, MRSA can be identified. Septicemia is diagnosed not only by the isolation of the organism in blood culture. It should be correlated with total count, CRP like lab investigations and clinical features. Sometimes repeated blood culture is needed to confirm the diagnosis and to assess the prognosis. Methicillin resistant Coagulase negative Staphylococcus aureus and Methicillin resistant Staphylococcus aureus are more challenges in management of neonatal septicemia. MRSA shows resistant to many of the drugs including Gentamycin, Amikacin and Piperacillin+Tazobactam. It is sensitive only to Vancomycin, Linezolid antibiotics. Early diagnosis and prompt treatment based on the Antibiotic sensitivity test results will prevent the spread of drug resistant strain and also decrease the morbidity and mortality in NICUs. Implementation  of  aggressive  infection    control  measures  and  appropriate  hand  hygine   practices   are  enforce  for  health care  workers   and  proper  isolation  of  neonates in NICU   and  surveillance  of  nasal  carrier  of  health  care   persons   and  treatment  with  nasal  mupirocin  3  times  per  day  for  5  consective    days  are  very  important  in preventing   mrsa  out  breaks  and   neonatel  septisemia.

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