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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(5): 2788-2792
DOI: https://doi.org/10.20546/ijcmas.2017.605.313


Hyperprolactinemia in Systemic Lupus Erythematosus
Menaka Shanthi Kandasamy1*, K. Pramila1 and M. Divya2
1Department of Biochemistry, ICH & HC, MMC, Egmore, Chennai- 600008, Tamil Nadu, India 2Department of Biochemistry, Government Omandurar Multispeciality Hospital, Chennai, Tamil Nadu, India
*Corresponding author
Abstract:

Prolactin, the protein hormone synthesized and secreted predominantly by anterior pituitary gland plays major role in galactopoeisis. The secretion of prolactin is not confined to pituitary alone; there are many immune cells in our body that mediate secretion of prolactin. The prolactin secreted by these immune cells functions as a cytokine that mediate proliferation and maturation of T and B Lymphocytes. Thus prolactin is a dual function protein, as a hormone and as a cytokine. The effect of prolactin over proliferation of T cells has unleashed the possible pathophysiological role of prolactin in several autoimmune disorders. In the present study we compared the level of prolactin in lupus patients with healthy controls. Prolactin levels were significantly elevated in lupus patients compared to healthy controls (P<0.05). This proves the possible pathophysiological role of prolactin in systemic lupus erythematosus. Hence utilization of prolactin antagonists can have significant role in therapy of systemic lupus erythematosus as well as in preventing the complications associated with systemic lupus erythematosus.


Keywords: Prolactin, Cytokine, Autoimmune disorders, Pathophysiological role, Systemic Lupus Erythematosus.
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How to cite this article:

Menaka Shanthi Kandasamy, K. Pramila and Divya, M. 2017. Hyperprolactinemia in Systemic Lupus Erythematosus.Int.J.Curr.Microbiol.App.Sci. 6(5): 2788-2792. doi: https://doi.org/10.20546/ijcmas.2017.605.313