Hepatitis C infection is a liver disease caused by the hepatitis C virus (HCV). It is one of the important risk factor causing acute to chronic illness in form of altered liver functions or development of chronic hepatitis, cirrhosis, hepatocellular carcinoma and liver failure. In India reported prevalence rates vary widely in range of 0.09%-2.02%. This retrospective study was carried out in patients attending GMERS hospital, Valsad, South Gujarat during January 2016 to December 2016. Serum samples were collected and screened for antibody against HCV by ELISA method. Result: Of the 7089 patients tested in this period 20 (0.28%) were found to be positive for HCV antibody, which includes 10(0.14%) males and 10(0.14%) females, the most common affected age group was ≥50 years. Conclusion: The present study highlights current scenario of HCV infection in our tertiary care hospital, it may help to detect target group for early detection and treatment in order to prevent complication.

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