National Academy of Agricultural Sciences (NAAS)
|
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
This study is a survey to reveal the sero-positivity rate of H. pylori in ITP, versus healthy Egyptians. We also aimed at correlating H. pylori antibody titre with the severity of ITP. This study included 293 Egyptians; 135 ITP patients and a control group of 158 individuals. CBC was done to determine platelet counts. Quantitative determination of H. pylori IgM and IgG was performed using Monobind, ELISA kit. Sero-positivity for H pylori IgM among controls (54.4%) was found to be significantly higher than among ITP patients (28.9%), p=0.0001. However, there was no significant difference between sero-positivity for H pylori IgG among controls (79.7%) and ITP patients (77.7%), p=0.680. A significantly higher mean level of IgG antibodies was detected among ITP patients (96.27 U/ml) compared to controls (83.735 U/ml), p=0.001. A significant negative correlation existed between H pylori IgM, IgG titres and platelet counts of ITP patients, r=-0.34 & r=-0.385, respectively, p = 0.001. The sero-prevalence of H pylori infection is high among Egyptians. Our results confirm reports proposing that antibodies produced against H. pylori infection might cross react with platelet antigens. ITP patients should be tested for H. pylori antibodies to receive triple therapy.
Citations |
 |
 |
 |
 |
