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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(5): 2482-2492
DOI: https://doi.org/10.20546/ijcmas.2017.605.278


Prevalence of Helicobacter pylori Antibodies in Egyptians with Idiopathic Thrombocytopenic purpura and in the General Egyptian Population: A Comparative Study
Nesren F. Hanafi1, Irene L. Mikhael2 and Doreen N. Younan3*
1Department of Microbiology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
2 Department of Haematology, Medical Research Institute, Alexandria University,Alexandria, Egypt
 3Department of Clinical Pathology, Faculty of Medicine, Alexandria University,Alexandria, Egypt
*Corresponding author
Abstract:

This study is a survey to reveal the sero-positivity rate of H. pylori in ITP, versus healthy Egyptians. We also aimed at correlating H. pylori antibody titre with the severity of ITP. This study included 293 Egyptians; 135 ITP patients and a control group of 158 individuals. CBC was done to determine platelet counts. Quantitative determination of H. pylori IgM and IgG was performed using Monobind, ELISA kit. Sero-positivity for H pylori IgM among controls (54.4%) was found to be significantly higher than among ITP patients (28.9%), p=0.0001. However, there was no significant difference between sero-positivity for H pylori IgG among controls (79.7%) and ITP patients (77.7%), p=0.680. A significantly higher mean level of IgG antibodies was detected among ITP patients (96.27 U/ml) compared to controls (83.735 U/ml), p=0.001. A significant negative correlation existed between H pylori IgM, IgG titres and platelet counts of ITP patients, r=-0.34 & r=-0.385, respectively, p = 0.001. The sero-prevalence of H pylori infection is high among Egyptians. Our results confirm reports proposing that antibodies produced against H. pylori infection might cross react with platelet antigens. ITP patients should be tested for H. pylori antibodies to receive triple therapy.


Keywords: Helicobacter pylori, Seropositivity, ITP, Autoimmune disease, Platelets
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How to cite this article:

Nesren F. Hanafi and Doreen N. Younan. 2017. Prevalence of Helicobacter pylori Antibodies in Egyptians with Idiopathic Thrombocytopenic purpura and In the General Egyptian Population: A Comparative Study.Int.J.Curr.Microbiol.App.Sci. 6(5): 2482-2492. doi: https://doi.org/10.20546/ijcmas.2017.605.278