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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(5): 2279-2286
DOI: https://doi.org/10.20546/ijcmas.2017.605.254


Bacteriological Profile of Uropathogens and their Antimicrobial Susceptibility Pattern in Isolates from a Tertiary Care Hospital
Sundararajan Thangavel1, Gomathi Maniyan1*, S. Vijaya2 and C. Venkateswaran2
1Department of Microbiology, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India
2Lab. Technician, Salem, Tamil Nadu, India
*Corresponding author
Abstract:

Urinary Tract Infection (UTI) is one of the most common infections observed in clinical practice among the community and hospitalized patients. Since the pattern of susceptibility is constantly changing, monitoring the changing trends has become more important. It provides information of the pathogenic organisms isolated from patients as well as assists in choosing the appropriate antimicrobial therapy. This retrospective study aims to analyze various uropathogens and their antimicrobial susceptibility pattern which would assist in selecting the most appropriate antibiotic therapy and for treatment of UTI in a tertiary care hospital. 700 urine isolates were studied retrospectively from November 2016 to January2017 which were cultured on to Blood agar and MacConkey agar plate. The plates that showed colonies >105 were considered significant and were identified by standard biochemical tests & sensitivity of the organisms was performed by Kirby – Bauer method on Mueller Hinton agar. Out of the 700 samples processed,48.6% (340)  gave positive urine culture, of which 73 (61.86%) were Escherichia coli 69% (107), Klebsiella spp.,11.6%(18), Proteus spp., 9.7%(15),  pseudomonas spp.,8.4% (13),  Acinetobacter spp.,1.3%(2) and Coagulase Negative Staphylococcus(CONS) 67% (130), Candida spp.,24.7%(48), Enterococci spp., 8.3%(16) respectively. Susceptibility patterns of each isolates have been determined. Resistance pattern observed was ESBL was about 87%, MBL 8% and AmpC7% among the Gram negative organisms. This study discourages the indiscriminate use of antibiotics which in turn would prevent further development of bacterial drug resistance. For this, a proper knowledge of susceptibility pattern of uropathogens is necessary before prescribing empirical antibiotic therapy.


Keywords: Urinary tract infection, Antimicrobial susceptibility, Extended-spectrum-lactamases, Amp C, Metallo Beta Lactamases (MBL)
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How to cite this article:

Sundararajan Thangavel, Gomathi Maniyan, S. Vijaya and Venkateswaran, C. 2017. Bacteriological Profile of Uropathogens and their Antimicrobial Susceptibility Pattern in Isolates from a Tertiary Care Hospital.Int.J.Curr.Microbiol.App.Sci. 6(5): 2279-2286. doi: https://doi.org/10.20546/ijcmas.2017.605.254