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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here
ICV 2023: 95.56
Index Copernicus ICI Journals Master List 2023 - IJCMAS--ICV 2023: 95.56
For more details click here
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Original Research Articles                      Volume : 15, Issue:4, April, 2026
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38
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Int.J.Curr.Microbiol.App.Sci.2026.15(4): 243-250
DOI: https://doi.org/10.20546/ijcmas.2026.1504.029


Association of HLA-DQB1 Gene Polymorphisms to the Progression of Viral Hepatitis B in Burkina Faso: A Case-Control Study

Serge Theophile Soubeiga1*, Lacina Ouattara2, Véronique Zongo2, Lassina Traore2, Abel Pegdwende Sorgho3, Albert Théophane Yonli3, Wendkuuni Florencia Djigma2 and Jacques Simpore2,3
1Institut de Recherche en Sciences de la Santé (IRSS), Ouagadougou, Burkina Faso 2Laboratoire de Biologie Moléculaire et de Génétique Moléculaire (LABIOGENE), Université Joseph Ki-Zerbo, Ouagadougou, Burkina Faso 3Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso
*Corresponding author
Abstract:

Clinical outcomes following exposure to hepatitis B virus vary enormously from spontaneous clearance to chronic hepatitis B, often progressing to liver cirrhosis and hepatocellular carcinoma. The presence and expression of polymorphisms in the HLA-DQB1 gene have been shown to correlate with spontaneous clearance and susceptibility to HBV infection. This study aimed to determine the association of HLA-DQB1 gene polymorphisms with chronic hepatitis B infection, cirrhosis, and HBV-related HCC in Burkina Faso. This case-control study was conducted in Ouagadougou, Burkina Faso, from August 2022 to May 2023. It characterized the HLA-DQB1 gene polymorphism (HLA-DQB1*0303, HLA-DQB1*0502, HLA-DQB1*0604) in 111 participants stratified into four groups: HCC (n=35), cirrhosis (n=13), chronic hepatitis B (CHB, n=37), and healthy controls (n=26). HLA-DQB1*03: 03, *05: 02, and *06: 04 alleles were characterized using PCR with sequence-specific primers (PCR-SSP). Data were analyzed using SPSS version 21 and R version 4.3.1. Our data suggest that HLA-DQB1*0502 (OR=28.4; 95%CI= 5.7-141.3; p-value <0.01; OR=7.1; 95%CI = 1.43-35.02 and p-value <0.01) was a risk factor for progression from hepatitis B to CHB and HCC. However, this allele also appeared to have a protective effect against cirrhosis (OR=0.03; 95%CI=0.004-0.305; p-value=<0.01). Carriers of the HLA-DQB1*0303 allele iniquitously had a higher risk of developing cirrhosis following chronic HBV infection (OR=29.4; CI95%=3.4-254.67, p-value<0.01). The simultaneous absence of HLA-DQB1*0502/HLA-DQB1*0604 alleles showed statistically significant values in healthy controls versus patients with HCC (58.5% versus 41.5%) (OR=0.03; CI95%=0.02-0.38; p-value<0.01). Our results revealed that carrying the HLA-DQB1*0502 allele could induce susceptibility to the progression of infection to critical stages, and the HLA-DQB1*0303 allele could be protective against the progression of hepatitis B.


Keywords: HBV, HLA-DQB1, polymorphisms, HLA, Cirrhosis, HCC, CHB

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How to cite this article:

Serge Theophile Soubeiga, Lacina Ouattara, Véronique Zongo, Lassina Traore, Abel Pegdwende Sorgho, Albert Théophane Yonli, Wendkuuni Florencia Djigma and Jacques Simpore. 2026. Association of HLA-DQB1 Gene Polymorphisms to the Progression of Viral Hepatitis B in Burkina Faso: A Case-Control Study.Int.J.Curr.Microbiol.App.Sci. 15(4): 243-250. doi: https://doi.org/10.20546/ijcmas.2026.1504.029
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