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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(5): 1623-1629
DOI: https://doi.org/10.20546/ijcmas.2017.605.177


Colonization with Antibiotic-Resistant E. coli in Commensal Fecal Flora of Newborns
Amey Tule and Umesh Hassani*
Department of Microbiology, NKP Salve Institute of Medical Sciences, Hingna Road, Nagpur, India
*Corresponding author
Abstract:

Bacterial resistance to antibiotics represents one of the most significant global health challenges of this century. Although the role of commensal bacteria in providing a reservoir of antibiotic resistance has been acknowledged for some time these bacteria have not been studied extensively. The purpose of the present paper is to prospectively determine the presence of Multi drug resistant E. coli in commensal fecal flora of Newborns who are not receiving any antibiotics. After receiving parental consent 30 neonates less than 1month of age of either sex, hospitalized in the pediatric unit of NKP Salve Institute of Medical Sciences, not recently exposed to antibiotics were enrolled along with 30 neonates less than 1month of age admitted in NICU on treatment with various antibiotics. E. coli isolates from Stool samples were identified by standard biochemical tests & Antibiotic susceptibility was tested by the Kirby-Bauer disk diffusion method on Mueller-Hinton agar. The Antibiogram of both the groups was compared to determine whether antibiotic therapy results in increase in the percentage of drug resistant E. coli population in the commensal fecal flora. In the newborns, who were not given antibiotics, resistance to Ampicillin was 100%, followed by Co-trimoxazole 27(96.42%). Highest sensitivity was observed to Amikacin 24(85.71%) followed by Gentamicin 16(57.14%).60% isolates were resistant to more than 3 drugs. In Newborns who were on various antibiotics, 100% resistance was seen to Ampicillin and Ceftriaxone followed by Co-trimoxazole 27(96.42%). Highest sensitivity was observed with Chloramphenicol 13(46.42). 11 isolates (39.28%) were sensitive to Amikacin and Tetracycline each. 90% isolates were resistant to more than 3 drugs.


Keywords: Multi-drug resistance, Prophylactic antibiotics, Antibiotic determinants.
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How to cite this article:

Amey Tule, Umesh Hassani. 2017. Colonization with Antibiotic-Resistant E. coli in Commensal Fecal Flora of Newborns.Int.J.Curr.Microbiol.App.Sci. 6(5): 1623-1629. doi: https://doi.org/10.20546/ijcmas.2017.605.177