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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 12, Issue:3, March, 2023

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2023.12(3): 81-88
DOI: https://doi.org/10.20546/ijcmas.2023.1203.011


Study of the HIV-1 RNA Levels and CD4+ Cells Counts in HIV Infected Patients
Neelam Chauhan1, Anshusharma1, Shiv Kumar1, Neera Samar2 and Madhubala Mishra1*
1Department of Microbiology, 2Department of Medicine, RNT government Medical College,Udaipur, Rajasthan, India
*Corresponding author
Abstract:

HIV infection is a global pandemic. There is an inverse relationship between CD4 counts and degree of immunosuppression. The present study aim to assess the use of viral load (HIV RNA) and CD4 cell counts in the monitoring of HIV progression and its correlation. This period of 20 months study was conducted on 300 seropositive patients attending ICTC in Department of Microbiology at the tertiary care hospital, fulfilling inclusion and exclusion criteria. CD4 counts were estimated at baseline (Pre ART) and after 6 months and 12 months. Viral load test had done at 6 and 12 months of Post ART. This study didn’t show any significant comparison between HIV RNA levels and CD4 cell counts after 6 months of ART treatment, but after 12 months there was significant negative linear correlation. 12 months of Post ART, TND number of patients increased from 152 patients to 215 patients. Patients who had VL>1000 copies/ml decreased from 27 patients to 10, only 1 patient showed static CD4 counts but achieved TND of viral load. We can conclude that combined use of CD4 and Viral load prognostic markers should prove useful in individual patient management and in the design and evaluation of therapeutic trials.


Keywords: HIV, CD4 cells counts, viral load, HIV RNA Levels, TND, ART

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How to cite this article:

Neelam Chauhan, Anshusharma, Shiv Kumar, Neera Samar and Madhubalamishra. 2023. Study of the HIV-1 RNA Levels and CD4+ Cells Counts in HIV Infected Patients.Int.J.Curr.Microbiol.App.Sci. 12(3): 81-88. doi: https://doi.org/10.20546/ijcmas.2023.1203.011
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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