National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Nicotina tabacum is a plant native to South America of the Solanaceae family and is widely used in the African pharmacopoeia to combat several diseases, including digestive parasitosis. The objective of the present study was to investigate the in vitro nematodicidal activity of the aqueous extract of N. tabacum leaves against Ascaridia galli parasites of the small intestine of chickens. The study consisted of a contact mortality test. Harvested A. galli adults were exposed to seven drug preparations including six different concentrations (4, 8, 16, 32, 64, and 128mg/ml Phosphate Buffer Saline) of the aqueous plant extract and a positive reference preparation (Levamisole at 4mg/ml PBS). The PBS served as a negative control. The test was repeated six times. The results obtained showed, after 8 hours of exposure, significant mortalities of 50 to 100%. The study showed a dose-dependent effect during the test. The mortality rates noted could be attributed to chemical compounds (alkaloids, quinine derivatives, polyphenols, gall tannins, flavonoids, steroids and triterpenoids, saponosides, reducing compounds and coumarins) with antiparasitic effect, detected through phytochemical screening. This study shows that N. tabacum has a nematodicidal effect on A.galli. However, further tests are envisaged to confirm this efficacy.
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