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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(5): 603-607
DOI: https://doi.org/10.20546/ijcmas.2017.605.069


Immune Mediated Haemolytic Anaemia Secondary to Sheathed Microfilaria – A Case Report
M. Ashwini* and Usha Narayana Pillai
Department of Veterinary Clinical Medicine, College of Veterinary and Animal Sciences, Mannuthy, India
*Corresponding author
Abstract:

A one year old female Labrador dog was presented to University Veterinary Hospital Kokkalai, with a history of anorexia, weakness, blood in urine and faeces. On physical examination mucous membranes were pale icteric, fever (105.30F), tachypnoea was noticed. Abdominal palpation revealed splenomegaly which was confirmed by ultrasonography. Haemotological examination revealed leucocytosis, severe macrocytic hypochromic anaemia (VPRC-9.4%) and thrombocytopenia. Wet film was positive for microfilaria and confirmed as brugiaspp on Giemsa staining of thick blood smear. Leptospirosis was ruled out by MAT. Biochemical studies showed hyperglobulinema, elevated ALT and indirect bilirubin. The blood was positive for saline agglutination test and further antiglobulin test was carried out at 370C using VMRD polyvalent Coombs’ reagent which was positive at 1:32 dilution. Treatment was initiated with a dexamethasone @ 0.5 mg/kg IV for 7 days, then tapered to 0.25 mg/kg for 7 days and 0.125 mg/kg for next 7 days PO. The pet was transfused with 250 ml of whole blood on the day of admission and supportive therapy with amoxicillin-clavulanic acid 600mg IV (14 days), levamisole @ 10mg/kg for 10 days, pantoprazole and haematinics were given. The pet made an uneventful recovery.


Keywords: Sheathed microfilaria; Brugia spp; Immune mediated haemolyticanaemia (IMHA); Coombs’ test
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How to cite this article:

Ashwini, M., and Usha Narayana Pillai. 2017. Immune Mediated Haemolytic Anaemia Secondary to Sheathed Microfilaria – A Case ReportInt.J.Curr.Microbiol.App.Sci. 6(5): 603-607. doi: https://doi.org/10.20546/ijcmas.2017.605.069