Fungi, bacteria, mycoplasma, Spiroplasma, virus, viroid, phanerogamic plant parasites, and other macro pests are all agents, which lead to suffering of plants, this effects the tropic levels above producers who are feeding on them for survival. Science of pathology shouldn’t be confined to humans itself (I mean understanding human diseases), it’s equally important that the science of plant pathology must be given equal importance as medicine. We have seen many epiphytotic in past, Irish famine which led to death of approx 1 million people and migration of 1.5 million Irish, chestnut blight, Dutch elm disease, lethal yellowing of coconut (in Caribbeans and south America), powdery mildew, downy mildew (Europe especially UK and France), rusts and etc. These incidents in past made us realize how important its to have concern towards crop protection orelse people die out of food or this may disturb ecology by eliminating a plant species which was about to happen in elm and chestnut. Hence its responsibility of plant pathologists to serve humanity the way doctors serve human health. Hence emerged methods to deal with plant pathogens and human being in course of history discovered different methods of controlling pathogens which include agronomic cultural methods, botanical sand etc. and then make chemical method as science advanced, chemistry revolutionized however chemicals were used in ancient antiquity i.e., Homer suggested use of Sulphur far back in 1000 BC and Tillet and Prevost suggested use of copper sulphate for smuts. However, after World War 2 the use of chemicals increased in accelerated rate. Apart from using chemicals (Sulphur for PM, Bordeaux mixture for DM, Copper Sulphate for Smut – which were using in past in history). Keeping all these apart, in 19^th century ending till 20^th century middle emergence of science of genetics and improvements in plant breeding gave us new technology to make disease resistant plants. And in 20^th century ending, improvements in biotechnology, and coming together of plant breeding and biotechnology enabled us further to make disease resistant plants easily. The 5^th generation breeding which includes markers and biotechnology as enabled us in pyramiding genes, MABC enabled us to transfer genes governing biotic stress resistance from wild plants into agronomically desirable cultivated plants (introgression), the best classic example being transfer of Xa21, xa5 and xa13 genes into Pusa Basmati – 1 making it Improved Pusa Basmati – 1. Even the conventional breeding methods are still in major use to develop disease resistance plants i.e., selection, introduction, hybridization and etc. The review article is made in very holistic manner which includes all major historic important pathogens and breeding strategies employed to improve them and it includes rusts, Panama wilt, Coffee rust, bacterial blight of rice and etc.

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