National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Endophytes’ natural habits are within plant tissues. The study aims to evaluate the antibacterial and antioxidant activity of bioactive compounds synthesized by endophytic fungi obtained from leaves of Azadirachta indica (AI), Talinum fruticosum (TF), Telfairia occidentalis (TO), Mangifera indica (MI) and Vernonia amygdalina (VA). The compounds produced by the isolated endophytic fungi from the medicinal plants used in this study were extracted with ethylacetate and subjected to antibacterial using agar well diffusion method while the antioxidant activities was determined using theor ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. Four fungal species were isolated from the plants and were identified to be Mucor plumbeus, Rhizopus, Aspergillus niger and Penicillium roquefortil. Alkaloids, saponins and steroids were detected in all the extracts while tannin was not detected. Flavonoids were detected in AI, TO and MI; flavonoids was detected in TO, TF and VA. All the extracts obtained from this study showed good antioxidant activity with TO having the highest diphenyl 2-picryhydrazyl (DPPH) radical scavenging activity compared to the other extracts. All the extracts inhibited the growth of both E. coli and S. aureus with TO having the highest diameter zone of inhibition of 26±0.88 and 35±1.78 respectively. The effect of AO, SJ1, SJ2 was bacteriocidal against S. aureus and E. coli. TC1 was bacteriocidal against S. aureus but bacteriostatic against E. coli while TC2 was bacteriostatic for both S. aureus and E. coli. The compounds produced by the isolated fungi possess both antioxidant and antibacterial activity which can be used for development of new therapeutics.
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