National Academy of Agricultural Sciences (NAAS)
|
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Microbial biofilms in indwelling urinary catheters promote persistent and recurrent infections. This is due to their complex nature and resistance to commonly used antibiotics that are a challenge to management of catheter associated urinary tract infection (CAUTI). The present study was conducted to detect biofilm production by isolates from patients with CAUTI, and their association with antibiotic resistance. A prospective study was done on 344 hospitalized patients in intensive care units, with indwelling urinary catheter of more than 2days. CAUTI was diagnosed based on the CDC guidelines 2015. Uropathogens were identified and their antibiotic susceptibility was performed following standard microbiological methods. Biofilm detection was done by tube adherence method. Proportion and percentages, and fisher exact test were used to analyse the results. Among 344 patients catheterised, 41 developed CAUTI. The most common organism isolated was E.coli (51.2%), followed by Klebsiella pneumoniae (24.4%). Among the isolates 29 (71%) were biofilm producers. Biofilm producing strains showed relatively higher antibiotic resistance than non-producers. Among the 66% of multi drug resistant (MDR) isolates, 64% were biofilm producers, showing significant association between biofilm production and multidrug resistance. There was statistical significance between patients on long term antibiotics (>5 days) and the development of MDR infection in them. (p<0.027). Increased prevalence of MDR among biofilm producers was significant posing a problem in CAUTI management. Biofilms producers, are highly resistant to several conventional management approaches. Hence newer management strategies may be needed.
Citations |
 |
 |
 |
 |
