National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Isatin(2, 3-dioxindate), a particularly effective scaffold with a variety of pharmacological actions, has been developed due to its therapeutic significance in organic and medicinal chemistry. Many researchers have been drawn to this skeleton because of its diverse biological response profile and its multiple possibilities against a variety of activities. Sandmeyer's and Stolle processes are two typical ways for synthesizing isatin derivatives. Many researchers have taken advantage of the isatin moiety by using NH at the first position, C2 and C3 carbonyl positions for the creation of numerous derivatives with varying biological activities. Design strategies for the synthesis of isatin-containing heterocyclics have been discussed in this review paper using several approaches. The chemistry, synthesis, biological and pharmacological action, SAR, and advanced uses of the isatin moiety are all covered in this paper. The progress in the use of isatins for organic synthesis over the previous twenty-five years, as well as a study of their biological and pharmacological properties, are given, together with supplemental data.
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