This investigation conducted to study the influence of Egyptian propolis on immunological responses with special reference to cytokine levels of infected rats with Toxoplasma gondii and treated with 0.1 ml propolis day after day till the end of the experiment (28 days). Immune response of rats was evaluated weekly. The results revealed that the propolis was the highest in the toxoplasma antibodies titer when comparing with control group from the 2nd week to the end of experiment. Serum level of cytokines was consistently higher in the treated and propolis infected rats compared with controls. Serum cytokine levels of rats after infection with T. gondii showed significantly reduced levels of tumor necrosis factor-α (TNFα), IL-1β and IL-6 levels if compared to those in infected control rats or propolis treated group.

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