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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2019) [Effective from January 1, 2019]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(3): 397-414
DOI: http://dx.doi.org/10.20546/ijcmas.2016.503.047


A Comparative Study on Propolis and Pollen Extracts: Chemical Profile Analysis, Antioxidant and Anticancer Activity
Hala M. Abu Shady1, Wafaa F. mohamed2, ElSayed F. Sayed-Ahmed3 and Sara A. Amer3*
1Faculty of Science, Ain Shams University, Egypt
2Ain Shams University Specialized Hospital, Egypt
3Food Technology Research Institute (FTRI), Agricultural Research Centre (ARC), Egypt
*Corresponding author
Abstract:

Propolis and pollen are apicultural products exhibits valuable pharmacological and biological properties attributed to the presence of polyphenols. So this study designed to investigate the chemical composition, antioxidant and anticancer activity of propolis and pollen extracts. Propolis and pollen extracts were obtained by different concentrations of ethanol. Phenolic compounds of the extracts were detected by high performance liquid chromatography (HPLC) analysis. 25 phenolic compounds and 12 flavonoids from propolis and pollen extracts were identified. The major phenolic compounds were ethyl vanillin and hisperidin. 70% ethanolic extracts of propolis (EEP70) and combined mixtures of ethanolic propolis and pollen extracts (EPP70) has found to exhibit high antioxidant activity which has been measured by 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) assay method. All tested extracts show cytotoxic activity against the two tested cancer cell lines: breast cancer (MCF-7) and liver cancer (Hep-G2) cell lines. Generally, 70% ethanolic extract of propolis (EEP70), water extract of propolis (WEP) and combined mixtures of water extracted propolis and pollen (WPP) show the highest cytotoxic activity. This study may be useful in developing functional foods with high dietary antioxidant content or chemopreventive anticancer drugs with a potential to influence tumor cell progression.


Keywords: Propolis and Pollen Extracts, Antioxidant and Anticancer Activity.
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How to cite this article:

Hala M. Abu Shady, Wafaa F. mohamed, ElSayed F. Sayed-Ahmed and Sara A. Amer. 2016. A Comparative Study on Propolis and Pollen Extracts: Chemical Profile Analysis, Antioxidant and Anticancer Activity.Int.J.Curr.Microbiol.App.Sci. 5(3): 397-414. doi: http://dx.doi.org/10.20546/ijcmas.2016.503.047