Follow
International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

Login as a Reviewer

Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

See Guidelines to Authors
Current Issues
Download Publication Certificate

Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2021.10(4): 853-859
DOI: https://doi.org/10.20546/ijcmas.2021.1004.089


SARS-CoV-2 Triggers Inflammatory and Cell Death in Experimental Infection by Activating Human Cells Caspases
Jardel Fábio Lopes Ferreira1, Murilo Tavares Amorim1*, Francisco Canindé Ferreira de Luna1, Gustavo Moraes Holanda2, Clebson Pantoja Pimentel2, Walter Félix Franco Neto3, Caroline Carvalho Pinto3, Ana Paula Sousa Araújo3, Gleissy Adriane Lima Borges3 and Ana Cecília Ribeiro Cruz
1Institute of Biological Sciences, Federal University of Pará, S. Augusto Corrêa, 01 - Guamá, Belém - PA, 66075-110, Brazil 2University of the Amazon, S. Quintino Bocaiúva, 1808 - Nazaré, Belém - PA, 66035-190, Brazil 3Arbovirology and Hemorrhagic Fevers Section, Evandro Chagas Institute, Highway BR-316 km 7 s/n - Levilândia, PA, 67030-000, Brazil
*Corresponding author
Abstract:

Apoptosis is a process that occurs in programmed physiological and non-physiological cell death. In morphological aspect, among apoptosis products, cell shrinkage, subsequent to the degeneration of the nucleus characterized by condensation of chromatin, followed by the nuclear membrane disappearance. In particular, apoptosis modulation in SARS-CoV infection seems to be directly associated with specific cell-type interactions, which can significantly influence the manifestations resulting from the pathology. Therefore, it is noted the need for studies that promote debates about the modulation of apoptosis in animals and humans, infected by SARS-CoV. Because the spread of SARS-CoV-2 has become the most recent threat to global health, the quest to understand the virus-host interaction mechanisms has become a challenge for public health, research and medical communities, especially due to the interposition of factors related to the evolutionary spectrum of the agent. Thus, given the urgency of the global health situation, the need to develop therapies and vaccines to combat Covid-19 due to the SARS-CoV-2 pandemic that the recent experimental data on the main molecules expressed during infection by SARS-CoV-2, can be an alternative for the development of new effective parameters in the control of the disease, is the recognition and the differential parallelism between the mediating molecules, by which the immune system recognizes and responds to specific CoV infections, acting to support the development of therapeutic strategies.


Keywords: Cell shrinkage, macrophages, parenchyma, phagocytic degradation
Download this article as Download

How to cite this article:

Jardel Fábio Lopes Ferreira, Murilo Tavares Amorim, Francisco Canindé Ferreira de Luna, Gustavo Moraes Holanda, Clebson Pantoja Pimentel, Walter Félix Franco Neto, Caroline Carvalho Pinto, Ana Paula Sousa Araújo, Gleissy Adriane Lima Borges and Ana Cecília Ribeiro Cruz. 2021. SARS-CoV-2 Triggers Inflammatory and Cell Death in Experimental Infection by Activating Human Cells Caspases.Int.J.Curr.Microbiol.App.Sci. 10(4): 853-859. doi: https://doi.org/10.20546/ijcmas.2021.1004.089