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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2016 - IJCMAS--ICV 2016: 92.3 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2017) [Effective from January 1, 2017]For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2016: 92.3
Index Copernicus ICI Journals Master List 2016 - IJCMAS--ICV 2016: 92.3
For more details click here
journals IJCMAS
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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2015: 85.95
NAAS RATING 2017: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(4): 2744-2752
DOI: https://doi.org/10.20546/ijcmas.2017.604.318


Screening of Inhibitory Activity against α-Amylase of Fungal Endophytes Isolated from Medicinal Plants in Uzbekistan
D.M. Ruzieva, L.I. Abdulmyanova, G.A. Rasulova, R.S. Sattarova* and T.G. Gulyamova
Department of Biochemistry and Biotechnology of Physiologically Active Compounds,Institute of Microbiology of the Academy of Sciences RU, Uzbekistan
*Corresponding author
Abstract:

Diabetes is a common metabolic disorder characterized by abnormally increased plasma glucose levels. Postprandial hyperglycemia plays an essential role in development of type 2 diabetes. Inhibitors of carbohydrate-hydrolyzing enzymes such as α-amylase retard the liberation of glucose from dietary complex carbohydrates and delay the absorption of glucose. The purpose of the study was to isolate and select α-amylase inhibitor-producing endophytic fungi from well-known medicinal plants used in the treatment for diabetes and inhabiting in Uzbekistan. The obtained data showed that 100 fungal endophytes isolated from 16 local antidiabetic plants produce metabolites with potent inhibiting activity in vitro (60-82%) and are expected to be a source for therapeutic agents in treatment of diabetes.


Keywords: Endophytic fungi, α-amylase, Inhibitory activity, Bio-active natural products
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How to cite this article:

Ruzieva, D.M., L.I. Abdulmyanova, G.A. Rasulova, R.S. Sattarova and Gulyamova, T.G. 2017. Screening of Inhibitory Activity against α-Amylase of Fungal Endophytes Isolated from Medicinal Plants in Uzbekistan.Int.J.Curr.Microbiol.App.Sci. 6(4): 2744-2752. doi: https://doi.org/10.20546/ijcmas.2017.604.318