National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Diabetes is a common metabolic disorder characterized by abnormally increased plasma glucose levels. Postprandial hyperglycemia plays an essential role in development of type 2 diabetes. Inhibitors of carbohydrate-hydrolyzing enzymes such as α-amylase retard the liberation of glucose from dietary complex carbohydrates and delay the absorption of glucose. The purpose of the study was to isolate and select α-amylase inhibitor-producing endophytic fungi from well-known medicinal plants used in the treatment for diabetes and inhabiting in Uzbekistan. The obtained data showed that 100 fungal endophytes isolated from 16 local antidiabetic plants produce metabolites with potent inhibiting activity in vitro (60-82%) and are expected to be a source for therapeutic agents in treatment of diabetes.
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